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Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer
O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown… Expand
A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes.
Human leukosialin (CD43) is a major sialoglycoprotein expressed on leukocytes and platelets. In order to investigate the transcriptional regulation of this gene, we have isolated a genomic DNA of 12… Expand
Transcriptional activation of human leukosialin (CD43) gene by Sp1 through binding to a GGGTGG motif.
Human leukosialin (CD43) is expressed on the surface of hematopoietic cells in cell-type specific and differentiation-stage-specific manners. Previously we found that the sequence from -53 to -40 was… Expand
Functional analyses of MeCP2 mutations associated with Rett syndrome using transient expression systems
- S. Kudo, Y. Nomura, M. Segawa, N. Fujita, M. Tamura
- Biology, Medicine
- Brain and Development
- 1 December 2001
Rett syndrome, an X-linked neurodevelopmental disorder, is a major cause of mental retardation in females. Recent genetic analyses have revealed that mutations in the methyl-CpG-binding protein gene… Expand
Mapping of a blast field resistance gene Pi39(t) of elite rice strain Chubu 111
We investigated the mode of inheritance and map location of field resistance to rice blast in the elite rice strain Chubu 111, and yield under severe blast conditions. Chubu 111 carries the complete… Expand
Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences.
Glycophorins A (GPA) and B (GPB) are two major sialoglycoproteins of the human erythrocyte membrane. Here we present a comparison of the genomic structures of GPA and GPB developed by analyzing DNA… Expand
Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.
- M. Misago, Y. Liao, +4 authors M. Fukuda
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 5 December 1995
Golgi alpha-mannosidase II (alpha-MII) is an enzyme involved in the processing of N-linked glycans. Using a previously isolated murine cDNA clone as a probe, we have isolated cDNA clones encompassing… Expand
Tissue-specific Transcriptional Regulation of Human Leukosialin (CD43) Gene Is Achieved by DNA Methylation (*)
The expression of human leukosialin (CD43), a major sialoglycoprotein on the surface of hematopoietic cells, is regulated in cell lineage-specific as well as differentiation stage-specific manners.… Expand
Identification of the crossing-over point of a hybrid gene encoding human glycophorin variant Sta. Similarity to the crossing-over point in haptoglobin-related genes.
- A. Rearden, H. Phan, T. Dubnicoff, S. Kudo, M. Fukuda
- Medicine, Biology
- The Journal of biological chemistry
- 5 June 1990
One of the human glycophorin variants, Stones (Sta), has been shown to be the product of a hybrid gene of which the 5'-half derived from the glycophorin B (GPB) gene whereas the 3'-half derived from… Expand
Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals.
Glycophorins A (GPA) and B (GPB) are specifically expressed in human erythrocytes and express MN and Ss blood group antigens. While the GPB gene produces one transcript, the GPA gene produces three… Expand