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Using immediate-early genes to map hippocampal subregional functions.
TLDR
IEG studies provide support for the role of the hippocampus in spatial and contextual learning and memory, its role in continuous encoding of ongoing experience, and septotemporal dissociations between memory and anxiety in the CA3 subregion.
Rapid Activation of Plasticity-Associated Gene Transcription in Hippocampal Neurons Provides a Mechanism for Encoding of One-Trial Experience
TLDR
It is demonstrated for the first time that a single brief experience, equivalent to a single crossing of a firing field, can trigger IEG expression required for long-term plasticity in the hippocampus.
Attention-Like Modulation of Hippocampus Place Cell Discharge
TLDR
The hippocampus place code is concluded to be a dynamic representation of the spatial information in the immediate focus of attention, implying that a covert, dynamic attention-like process modulates discharge on a ∼1 s time scale.
Understanding hippocampal activity by using purposeful behavior: place navigation induces place cell discharge in both task-relevant and task-irrelevant spatial reference frames.
TLDR
It is concluded that the effects of environmental manipulations can be understood with confidence only when the rat's purposeful behavior is used to formulate interpretations of the data, and hippocampal place cell activity is organized in multiple overlapping spatial reference frames.
Behavioral Evidence That Segregation and Representation Are Dissociable Hippocampal Functions
TLDR
The hypothesis that the segregation of relevant and irrelevant stimuli and stimuli association into representations are distinct hippocampus-dependent operations explains the pattern of sparing and impairment after the TTX injection in other place avoidance task variants, leading to the conclusion that stimulus separation and association representation are dissociable functions of the hippocampus.
Understanding hippocampal activity by using purposeful behavior: Place navigation induces place cell discharge in both task-relevant and task-irrelevant spatial reference frames
TLDR
It is concluded that the effects of environmental manipulations can be understood with confidence only when the rat's purposeful behavior is used to formulate interpretations of the data, and hippocampal place cell activity is organized in multiple overlapping spatial reference frames.
Place avoidance tasks as tools in the behavioral neuroscience of learning and memory.
TLDR
The development of the place avoidance tasks are described, the cognitive processes associated with performance are evaluated and the application of place avoidance in the testing of spatial learning after neuropharmacological, lesion and other experimental manipulations is explored.
Functional inactivation of the rat hippocampus disrupts avoidance of a moving object
TLDR
A specific role of the hippocampus in dynamic cognitive processes required for flexible navigation strategies such as continuous updating of information about the position of a moving stimulus is suggested.
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