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  • Influence
Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers
BACKGROUND Alcohol and tobacco dependence are highly comorbid disorders, with preclinical evidence suggesting a role for nicotinic acetylcholine receptors (nAChRs) in alcohol consumption.Expand
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Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers.
OBJECTIVE To examine the relationship between impulsivity and smoking cessation treatment response among adolescents. METHODS Thirty adolescent smokers participated in a high school based smokingExpand
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Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo–pituitary–adrenocortical axis
Abstract.Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcoholExpand
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Time to first cigarette in the morning as an index of ability to quit smoking: implications for nicotine dependence.
An inability to maintain abstinence is a key indicator of tobacco dependence. Unfortunately, little evidence exists regarding the ability of the major tobacco dependence measures to predict smokingExpand
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Suppression of the HPA axis stress-response: implications for relapse.
This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October 2004. ThisExpand
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Reasons for Electronic Cigarette Experimentation and Discontinuation Among Adolescents and Young Adults.
INTRODUCTION Understanding why young people try and stop electronic cigarette (e-cigarette) use is critical to inform e-cigarette regulatory efforts. METHODS We conducted 18 focus groups (N = 127)Expand
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Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms.
BACKGROUND Cigarette smoking rates in schizophrenia are higher than in the general population. OBJECTIVES To determine whether cigarette smoking modifies cognitive deficits in schizophrenia and toExpand
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Human Tobacco Smokers in Early Abstinence Have Higher Levels of β2* Nicotinic Acetylcholine Receptors than Nonsmokers
Nicotine, the addictive chemical in tobacco smoke, initiates its actions in brain through nicotinic acetylcholine receptors (nAChRs). In particular, nAChRs containing β2-subunits (β2*-nAChRs) theExpand
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A controlled trial of naltrexone augmentation of nicotine replacement therapy for smoking cessation.
BACKGROUND Many smokers remain refractory to current therapies, which only partially address weight gain after smoking cessation. Thus, this study evaluated whether naltrexone hydrochlorideExpand
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beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.
CONTEXT Available levels of nicotinic acetylcholine receptors containing the beta(2) subunit (beta(2)*-nAChR) are higher in recently abstinent tobacco smokers compared with participants who neverExpand
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