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Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer.
- Nadine Seubert, Y. Royer, +5 authors S. Constantinescu
- Medicine, Biology
- Molecular cell
- 1 November 2003
Binding of erythropoietin to the erythropoietin receptor (EpoR) extracellular domain orients the transmembrane (TM) and cytosolic regions of the receptor dimer into an unknown activated conformation.… Expand
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion
- S. Krishnakumar, D. Radoff, +8 authors J. Rothman
- Medicine, Biology
- Nature Structural &Molecular Biology
- 1 August 2011
The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an 'open' conformation, binding another SNAREpin and… Expand
Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.
- Kentaro Fujita, S. Krishnakumar, D. Franco, A. Paul, E. London, E. Wimmer
- Chemistry, Medicine
- 1 May 2007
Replication of poliovirus RNA takes place on the cytoplasmic surface of membranous vesicles that form after infection of the host cell. It is generally accepted that RNA polymerase 3D(pol) interacts… Expand
Calcium sensitive ring-like oligomers formed by synaptotagmin
- J. Wang, Óscar Bello, +6 authors James E. Rothman
- Medicine, Chemistry
- Proceedings of the National Academy of Sciences
- 8 September 2014
Significance Synaptotagmin-1 is the calcium sensor for synchronous neurotransmitter release. It couples calcium influx to the soluble N-ethylmaleimide–sensitive factor activating protein receptor… Expand
Re-visiting the trans insertion model for complexin clamping
We have previously proposed that complexin cross-links multiple pre-fusion SNARE complexes via a trans interaction to function as a clamp on SNARE-mediated neurotransmitter release. A recent NMR… Expand
Spatial relationship between the prodan site, Trp-214, and Cys-34 residues in human serum albumin and loss of structure through incremental unfolding.
Prodan (6-propionyl-2-(dimethylamino)-naphthalene), a competitive inhibitor of warfarin binding to human serum albumin (HSA) at drug site I, was used to determine the inter- and intradomain distances… Expand
The control of transmembrane helix transverse position in membranes by hydrophilic residues.
The ability of hydrophilic residues to shift the transverse position of transmembrane (TM) helices within bilayers was studied in model membrane vesicles. Transverse shifts were detected by… Expand
Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains
The initial, nanometer-sized connection between the plasma membrane and a hormone- or neurotransmitter-filled vesicle –the fusion pore– can flicker open and closed repeatedly before dilating or… Expand
Correction: Re-visiting the trans insertion model for complexin clamping
Glutamate-induced Assembly of Bacterial Cell Division Protein FtsZ*
- T. Beuria, S. Krishnakumar, +4 authors D. Panda
- Biology, Medicine
- The Journal of Biological Chemistry
- 7 February 2003
The polymerization of FtsZ is a finely regulated process that plays an essential role in the bacterial cell division process. However, only a few modulators of FtsZ polymerization are known. We… Expand