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Molecular diversity of spider venom
Spider venom, a factor that has played a decisive role in the evolution of one of the most successful groups of living organisms, is reviewed and special attention is given to the structure, properties, and biosynthesis of toxins of polypeptide nature.
Latarcins, Antimicrobial and Cytolytic Peptides from the Venom of the Spider Lachesana tarabaevi (Zodariidae) That Exemplify Biomolecular Diversity*
- S. Kozlov, A. Vassilevski, A. Feofanov, A. Y. Surovoy, Dmitry V Karpunin, E. Grishin
- BiologyJournal of Biological Chemistry
- 28 July 2006
Seven novel short linear antimicrobial and cytolytic peptides named latarcins were purified from the venom of the spider Lachesana tarabaevi and showed to adopt amphipathic α-helical structure in membrane-mimicking environment by CD spectroscopy.
A novel strategy for the identification of toxinlike structures in spider venom
We compared two different approaches to sequence information analysis from the expressed sequence tag (EST) library constructed for the venom glands of the spider Agelena orientalis. Some results…
An ERG Channel Inhibitor from the Scorpion Buthus eupeus*
The cloning, expression, and selectivity of BeKm-1 was shown to be a novel specific blocker of hERG1 potassium channels and represents a new subgroup of these toxins.
Analgesic Compound from Sea Anemone Heteractis crispa Is the First Polypeptide Inhibitor of Vanilloid Receptor 1 (TRPV1)*
The results can make an important contribution to the research into molecular mechanisms of TRPV1 modulation and help to solve the problem of overactivity of this receptor during a number of pathological processes in the organism.
The universal algorithm of maturation for secretory and excretory protein precursors.
TRPV1 activation power can switch an action mode for its polypeptide ligands
The double-gate model of TRPV1 activation suggests that APHC-polypeptides may stabilize an intermediate state during the receptor activation, and the action mode of APHCs is bimodal and depended on the activation stimuli strength.
Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia
The polypeptides APHC1 and APHC3 could be referred to as a new class of TRPV1 modulators that produce a significant analgesic effect without hyperthermia.
Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom.
Eight linear cationic peptides with cytolytic and insecticidal activity, designated cyto-insectotoxins (CITs), were identified in Lachesana tarabaevi spider venom and are the first example of molecules showing equally potent antimicrobial and insecticide effects.
Sea Anemone Peptide with Uncommon β-Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic Activity*
A new peptide, Ugr 9-1, was isolated from the sea anemone venom and was shown to inhibit the acid-sensing ion channel 3 (ASIC3) channel, which affects the ASIC3 channel, produces analgesic effects, and has a unique spatial structure and mechanism of action.