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Molecular diversity of spider venom
Spider venom, a factor that has played a decisive role in the evolution of one of the most successful groups of living organisms, is reviewed. Unique molecular diversity of venom components includingExpand
Latarcins, Antimicrobial and Cytolytic Peptides from the Venom of the Spider Lachesana tarabaevi (Zodariidae) That Exemplify Biomolecular Diversity*
Seven novel short linear antimicrobial and cytolytic peptides named latarcins were purified from the venom of the spider Lachesana tarabaevi. These peptides were found to produce lytic effects onExpand
A novel strategy for the identification of toxinlike structures in spider venom
We compared two different approaches to sequence information analysis from the expressed sequence tag (EST) library constructed for the venom glands of the spider Agelena orientalis. Some resultsExpand
An ERG Channel Inhibitor from the Scorpion Buthus eupeus*
The isolation of the peptide inhibitor of M-type K+ current, BeKm-1, from the venom of the Central Asian scorpion Buthus eupeus has been described previously (Fillipov A. K., Kozlov, S. A.,Expand
Analgesic Compound from Sea Anemone Heteractis crispa Is the First Polypeptide Inhibitor of Vanilloid Receptor 1 (TRPV1)*
Venomous animals from distinct phyla such as spiders, scorpions, snakes, cone snails, or sea anemones produce small toxic proteins interacting with a variety of cell targets. Their bites often causeExpand
The universal algorithm of maturation for secretory and excretory protein precursors.
  • S. Kozlov, E. Grishin
  • Biology, Medicine
  • Toxicon : official journal of the International…
  • 1 April 2007
During maturation, most proteins undergo different posttranslational modifications. In most simple cases, signal peptidases remove the signal or leader peptide from the precursors of the secretoryExpand
Spider toxins comprising disulfide‐rich and linear amphipathic domains: a new class of molecules identified in the lynx spider Oxyopes takobius
In addition to the conventional neurotoxins and cytotoxins, venom of the lynx spider Oxyopes takobius was found to contain two‐domain modular toxins named spiderines: OtTx1a, 1b, 2a and 2b. TheseExpand
Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia
Transient receptor potential vanilloid 1 receptors (TRPV1) play a significant physiological role. The study of novel TRPV1 agonists and antagonists is essential. Here, we report on theExpand
New polypeptide components from the Heteractis crispa sea anemone with analgesic activity
Two new polypeptide components which exhibited an analgesic effect in experiments on mice were isolated from the Heteractis crispa sea tropical anemone by the combination of chromatographic methods.Expand
Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom.
Eight linear cationic peptides with cytolytic and insecticidal activity, designated cyto-insectotoxins (CITs), were identified in Lachesana tarabaevi spider venom. The peptides showed antibioticExpand