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Using graph theory to analyze biological networks
TLDR
Att approaches, models and methods from the graph theory universe are demonstrated and ways in which they can be used to reveal hidden properties and features of a network are discussed to better understand the biological significance of the system. Expand
The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase.
TLDR
The results suggest that the THAP domain is a novel example of a DBD that is shared between cellular proteins and transposases from mobile genomic parasites. Expand
IMGT®, the international ImMunoGeneTics information system® 25 years on
TLDR
IMGT®, the international ImMunoGeneTics information system, is the global reference in immunogenetics and immunoinformatics and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data. Expand
Plant cytosine-5 DNA methyltransferases: structure, function, and molecular evolution.
TLDR
A conserved dipeptide that plays an important role in flipping the target base into the catalytic site of the C5-MTases was identified in all plant C5 -MTases under study. Expand
Search for potential markers for prostate cancer diagnosis, prognosis and treatment in clinical tissue specimens using amine-specific isobaric tagging (iTRAQ) with two-dimensional liquid
TLDR
The PCa proteome found can serve as a useful aid for the identification of improved diagnostic and prognostic markers and ultimately novel chemopreventive and therapeutic targets. Expand
Proteomics‐driven progress in neurodegeneration research
TLDR
A summary of the major contributions of proteomics technologies in the study of neurodegenerative and psychiatric diseases, in particular, in the detection of changes in protein levels and modifications related to these disorders is provided. Expand
Sample preparation and bioinformatics in MALDI profiling of urinary proteins.
TLDR
The results indicate that ultrafiltration, as well as direct dilution of urine in TFA, can provide information rich and reproducible spectra for mass ranges up to 20 kDa and the importance of the presence of peak reproducibility filters when generating disease classification models is suggested. Expand
Evolutionary scenarios of Notch proteins.
TLDR
Comparison of the organization of Notch syntenic genes among species supports the coordinated rearrangements during evolution for Ntch, PBX, and BRD families that may lead to possible functional relationships. Expand
Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases.
TLDR
The results of this study add further support to a previous hypothesis that RCMTs represent evolutionary intermediates of RNA (uridine-5)-methyltransferases and DNA (cytosine-5- methyltransferases), as well as the potential evolutionary relationships among the different eukaryotic RCMT subfamilies. Expand
IMGT/Collier-de-Perles: a two-dimensional visualization tool for amino acid domain sequences
TLDR
The IMGT/Collier-de-Perles specializes in the area of immunoglobulins (IG) or antibodies, T cell receptors (TR) and major histocompatibility (MH) of human and other vertebrate species as well as other proteins of the immune system of vertebrates and invertebrates. Expand
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