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Role of Brain Inflammation in Epileptogenesis
Inflammation is known to participate in the mediation of a growing number of acute and chronic neurological disorders. Even so, the involvement of inflammation in the pathogenesis of epilepsy andExpand
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NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat
Chronic infusion of nerve growth factor (NGF) into the forebrain of the adult rat produced increases in NGF receptor (NGF-R) mRNA hybridization, NGF-R immunoreactivity, choline acetyltransferaseExpand
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Localization and development of nerve growth factor-sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex
  • S. Koh, R. Loy
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 September 1989
In order to understand further the role of NGF in the development of NGF-sensitive basal forebrain neurons and their afferent connections to the hippocampus and neocortex, we have used monoclonalExpand
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Cellular injury and neuroinflammation in children with chronic intractable epilepsy
ObjectiveTo elucidate the presence and potential involvement of brain inflammation and cell death in neurological morbidity and intractable seizures in childhood epilepsy, we quantified cell death,Expand
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Decreased Glutamate Receptor 2 Expression and Enhanced Epileptogenesis in Immature Rat Hippocampus after Perinatal Hypoxia-Induced Seizures
Hypoxic encephalopathy is the most common cause of neonatal seizures and can lead to chronic epilepsy. In rats at postnatal days 10–12 (P10–12), global hypoxia induces spontaneous seizures andExpand
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Differential regulation of the low‐affinity nerve growth factor receptor during postnatal development of the rat brain
  • S. Koh, G. Higgins
  • Biology, Medicine
  • The Journal of comparative neurology
  • 15 November 1991
We studied the temporal and spatial localization of the low‐affinity nerve growth factor receptor (LNGF‐R) during the early postnatal period in rat brain in order to understand better theExpand
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Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures
Innate immunity mediated by microglia appears to play a crucial role in initiating and propagating seizure-induced inflammatory responses. To address the role of activated microglia in theExpand
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Microarray analysis of postictal transcriptional regulation of neuropeptides
Unlike adults, kainic acid (KA)-induced status epilepticus (SE) in immature rats causes neither cell death nor recurrent spontaneous seizures. To elucidate the mechanisms of these distinct responses,Expand
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Glial Activation Links Early‐Life Seizures and Long‐Term Neurologic Dysfunction: Evidence Using a Small Molecule Inhibitor of Proinflammatory Cytokine Upregulation
Summary:  Purpose: Early‐life seizures increase vulnerability to subsequent neurologic insult. We tested the hypothesis that early‐life seizures increase susceptibility to later neurologic injury byExpand
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Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system
NGF acts on responsive neurons by binding to specific NGF receptors on axonal termini, after which a critical biochemical signal is retrogradely transported to the cell body. The identity of theExpand
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