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Mammalian phosphoinositide kinases and phosphatases.
Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and internal membranes and play pivotal roles in the regulation of a wide variety of cellular processes.Expand
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The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
Phosphorylated derivatives of phosphatidylinositol, collectively referred to as phosphoinositides, occur in the cytoplasmic leaflet of cellular membranes and regulate activities such as vesicleExpand
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INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
UNLABELLED Inositol polyphosphate 4-phosphatase B (INPP4B) has been identified as a tumor suppressor mutated in human breast, ovary, and prostate cancers. The molecular mechanism underlying INPP4B'sExpand
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Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth byExpand
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Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.
Cleavage of the 5'-cap structure is involved in the major 5'-to-3' and nonsense-mediated mRNA decay pathways, and the protein complex consisting of Dcp1 and Dcp2 has been identified as the speciesExpand
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Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine
The metabolism of membrane phosphoinositides is critical for a variety of cellular processes. Phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P2] controls multiple steps of the intracellularExpand
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microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma
Previous studies showed that five miRNAs (miR-885-5p, miR-1274, miR-210-3p, miR-224 and miR-1290) were upregulated the most in clear cell renal cell carcinoma (ccRCC). Our focus was to understandExpand
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Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment
Treatment options for ovarian cancer patients remain limited and overall survival is less than 50% despite recent clinical advances. The lipid phosphatase inositol polyphosphate 4-phosphatase type IIExpand
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1 INPP 4 B is a PtdIns ( 3 , 4 , 5 ) P 3 phosphatase that can act as a tumor suppressor
Research Center for Biosignal, Akita University, Akita 010-8543, Japan Departments of Medical Biology, Pathology, Urology and Cell Biology, Akita University Graduate School of Medicine, AkitaExpand
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The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
While cellular GTP concentration dramatically changes in response to an organism's cellular status, whether it serves as a metabolic cue for biological signaling remains elusive due to the lack ofExpand
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