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The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor.
It is concluded that SapB is derived from RamS through proteolytic cleavage and the introduction of four dehydroalanine residues and two lanthionine bridges, providing an example of a morphogenetic role for an antibiotic-like molecule.
Morphogenetic surfactants and their role in the formation of aerial hyphae in Streptomyces coelicolor
The current understanding of one of these groups of proteins, the morphogenetic surfactants, is reviewed, with emphasis on the SapB protein of Streptomyces coelicolor.
New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae.
Anabaenopeptins I (1) and J (2), two new ureido bond-containing cyclic peptides, were isolated from the cultured cyanobacterium Aphanizomenon flos-aquae (NIES-81) as potent carboxypeptidase-A (CPA)
SapT, a lanthionine‐containing peptide involved in aerial hyphae formation in the streptomycetes
The developmentally complex soil microbe Streptomyces tendae secretes a hydrophobic peptide that restored to developmental mutants of S. coelicolor the ability to raise aerial hyphae, implying that the production of morphogenetic peptides may be common among the streptomycetes, but their ability to function as biosurfactants is conserved, their specific lantibiotic structure is not.
Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
We show that selection of drug-resistant bacterial mutants allows the discovery of antibacterial compounds. Mutant strains of a soil-isolated Streptomyces species that does not produce antibacterials
Isolation and identification of the antialgal compound, harmane (1-methyl-β-carboline), produced by the algicidal bacterium, Pseudomonas sp. K44-1
Twelve strains of algicidal bacteria were isolated from the surfacewater of the pond Shinobazu and the moat Ote-bori (Tokyo, Japan) and showed marked antialgal activity by the paper disk method.
Five new cyanobacterial peptides from water bloom materials of lake Teganuma (Japan)
Five new cyanobacterial peptides, named microginins T1 and T2 and anabaenopeptin T, were isolated from cyanob bacterial water bloom materials of lake Teganuma (Japan), collected in 1994, 1995 and 1997 and showed a unique pattern of inhibition when tested in assays for trypsin, plasmin, chymotrypsin and leucine aminopeptidase.
Aeruginosin 103-A, a thrombin inhibitor from the cyanobacterium Microcystis viridis.
Aeruginosin 103-A was isolated from the cultured freshwater cyanobacterium Microcystis viridis(NIES-103). Its structure was elucidated to be 1 on the basis of 2D NMR data. This linear peptide
An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum.
Three new compounds were isolated from the mushroom Hericium erinaceum and showed the protective activity against endoplasmic reticulum (ER) stress-dependent Neuro2a cell death, however, compounds 2 and 3 did not.