The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor.
- S. Kodani, M. Hudson, M. Durrant, M. Buttner, J. Nodwell, J. Willey
- BiologyProceedings of the National Academy of Sciences…
- 3 August 2004
It is concluded that SapB is derived from RamS through proteolytic cleavage and the introduction of four dehydroalanine residues and two lanthionine bridges, providing an example of a morphogenetic role for an antibiotic-like molecule.
New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae.
- M. Murakami, S. Suzuki, Y. Itou, S. Kodani, K. Ishida
- Chemistry, BiologyJournal of Natural Products
- 27 July 2000
Anabaenopeptins I (1) and J (2), two new ureido bond-containing cyclic peptides, were isolated from the cultured cyanobacterium Aphanizomenon flos-aquae (NIES-81) as potent carboxypeptidase-A (CPA)…
Morphogenetic surfactants and their role in the formation of aerial hyphae in Streptomyces coelicolor
- J. Willey, A. Willems, S. Kodani, J. Nodwell
- BiologyMolecular Microbiology
- 1 February 2006
The current understanding of one of these groups of proteins, the morphogenetic surfactants, is reviewed, with emphasis on the SapB protein of Streptomyces coelicolor.
Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
- T. Hosaka, M. Ohnishi-Kameyama, K. Ochi
- BiologyNature Biotechnology
- 1 May 2009
We show that selection of drug-resistant bacterial mutants allows the discovery of antibacterial compounds. Mutant strains of a soil-isolated Streptomyces species that does not produce antibacterials…
SapT, a lanthionine‐containing peptide involved in aerial hyphae formation in the streptomycetes
- S. Kodani, Michael A. Lodato, M. Durrant, F. Picart, J. Willey
- BiologyMolecular Microbiology
- 1 December 2005
The developmentally complex soil microbe Streptomyces tendae secretes a hydrophobic peptide that restored to developmental mutants of S. coelicolor the ability to raise aerial hyphae, implying that the production of morphogenetic peptides may be common among the streptomycetes, but their ability to function as biosurfactants is conserved, their specific lantibiotic structure is not.
Isolation and identification of the antialgal compound, harmane (1-methyl-β-carboline), produced by the algicidal bacterium, Pseudomonas sp. K44-1
- S. Kodani, Akiko Imoto, Atsushi Mitsutani, M. Murakami
- BiologyJournal of Applied Phycology
- 1 April 2002
Twelve strains of algicidal bacteria were isolated from the surfacewater of the pond Shinobazu and the moat Ote-bori (Tokyo, Japan) and showed marked antialgal activity by the paper disk method.
Five new cyanobacterial peptides from water bloom materials of lake Teganuma (Japan)
- S. Kodani, Shin Suzuki, K. Ishida, M. Murakami
- Biology, Chemistry
- 1 September 1999
Five new cyanobacterial peptides, named microginins T1 and T2 and anabaenopeptin T, were isolated from cyanob bacterial water bloom materials of lake Teganuma (Japan), collected in 1994, 1995 and 1997 and showed a unique pattern of inhibition when tested in assays for trypsin, plasmin, chymotrypsin and leucine aminopeptidase.
Isolation and Identification of the antialgal compound from algicidal bacterium Pseudomonas sp. K44-1
- S. Kodani, Akiko Imoto, Atsushi Mitsutani, M. Murakami
- Biology
- 2002
The antialgal compound was purified from the whole culture broth of Pseudomonas sp.
Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22.
- S. Kodani, Joanna Bicz, G. Challis
- Chemistry, BiologyOrganic and biomolecular chemistry
- 25 June 2013
Comparative LC-MS/MS analyses of iron-deficient culture supernatants from wild type S. antibioticus showed that scabichelin is the metabolic product of the cryptic gene cluster, strongly suggesting that it functions as a siderophore.
Aeruginosin 103-A, a thrombin inhibitor from the cyanobacterium Microcystis viridis.
- S. Kodani, K. Ishida, M. Murakami
- Biology, ChemistryJournal of Natural Products
- 19 June 1998
Aeruginosin 103-A was isolated from the cultured freshwater cyanobacterium Microcystis viridis(NIES-103). Its structure was elucidated to be 1 on the basis of 2D NMR data. This linear peptide…
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