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Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways.
Association of Csk to VE‐cadherin and inhibition of cell proliferation
- Ulf Baumeister, Ruth Funke, K. Ebnet, H. Vorschmitt, S. Koch, D. Vestweber
- BiologyThe EMBO journal
- 4 May 2005
The results suggest that the phosphorylated tyrosine residue 685 of VE‐cadherin and probably the binding of Csk to this site are involved in inhibition of cell growth triggered by cell density.
Comparative study of the intestinal mucus barrier in normal and inflamed colon
The large bowel mucus layer effectively prevents contact between the highly concentrated luminal bacteria and the epithelial cells in all parts of the normal colon.
Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation
Annexin A1 Regulates Intestinal Mucosal Injury, Inflammation, and Repair1
It is demonstrated that AnxA1-deficient animals exhibit increased susceptibility to dextran sulfate sodium (DSS)-induced colitis with greater clinical morbidity and histopathologic mucosal injury, and a role of endogenous AnXA1 in the protective and reparative properties of the intestinal mucosal epithelium is supported.
Investigating the role of proinflammatory CD16+ monocytes in the pathogenesis of inflammatory bowel disease
- S. Koch, T. Kucharzik, J. Heidemann, A. Nusrat, A. Luegering
- Medicine, BiologyClinical and experimental immunology
- 1 August 2010
The data suggest that lamina propria, but not peripheral blood, CD16+ monocytes are a crucial proinflammatory cell population in IBD, and a potential target for anti‐inflammatory therapy.
Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.
Extrinsic control of Wnt signaling in the intestine.
- S. Koch
- BiologyDifferentiation; research in biological diversity
- 1 September 2017
The life and death of epithelia during inflammation: lessons learned from the gut.
How inflammatory cytokines and other signaling molecules, directly or through cross talk, regulate epithelial homeostasis in the intestine is discussed, and parallels and differences in a few other organs are highlighted.
JAM‐A regulates epithelial proliferation through Akt/β‐catenin signalling
It is demonstrated that JAM‐A restricts intestinal epithelial cell (IEC) proliferation in a dimerization‐dependent manner, by inhibiting Akt‐dependent β‐catenin activation.