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Expression profiles of COUP-TF, DAX-1, and SF-1 in the human adrenal gland and adrenocortical tumors: possible implications in steroidogenesis.
TLDR
The results indicate that co-localization of COUP-TF, DAX-1, and SF-1 in NL was lost in adrenocortical tumors and that these orphan receptors play an important role in the regulation of steroidogenesis in human adrenals.
Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription.
TLDR
The studies indicate that Ubc9 functions as a novel COUP-TFI corepressor, the function of which is distinct from its SUMO-1 conjugating enzyme activity.
Molecular analysis of alpha-thalassemia in Nepal: correlation with malaria endemicity.
TLDR
The results suggest that the high frequency of alpha+-thalassemia may be due to biological adaptation to the malarial environment rather than to events such as a bottleneck, if neutral molecular evolution in the D-loop region of mitochondrial DNA is assumed.
Investigation of high salt intake in a Nepalese population with low blood pressure.
TLDR
There was no increase in BP with age in Kotyang's males, suggesting that the BP may be influenced by physical activity, fat-free mass and nutrient consumption in addition to the high Sodium intake, and that extremely high physical activity and very low %Fat could serve to mute the influence of high sodium intake.
Orphan Receptors Coup-TF and Dax-1 as Targets in Disordered CYP17 Expression in Adrenocortical Tumors
TLDR
The reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.
Molecular analysis of α-thalassemia in Nepal: correlation with malaria endemicity
TLDR
The results of a microepidemiological study on thalassemia in two neighboring populations in Nepal suggest that the high frequency of α+-thalassemia may be due to biological adaptation to the malarial environment rather than to events such as a bottleneck.
The distribution of hereditary erythrocytic disorders associated with malaria, in a lowland area of Nepal: a micro-epidemiological study
Abstract Among four ethnic groups in a lowland area of Nepal, the prevalences of abnormal haemoglobin, thalassaemia, glucose-6-phosphate-dehydrogenase (G6PD) deficiency, hereditary South–east Asian
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