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Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.
TLDR
The results suggest that unusual pharmacokinetics of UCN-01 in humans could be due, at least in part, to its specifically high binding to alpha1-acid glycoprotein. Expand
The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.
TLDR
The data in this paper are consistent with 4-hydroxylation of debrisoquine in both rat and human liver catalysed by a specific form of cytochrome P-450, and suggest that data on the specificity of this isoenzyme in the rat should be extrapolated to man with extreme caution. Expand
Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans.
TLDR
The high degree of binding of UCN-01 to human AGP causes a reduction in the distribution and clearance, resulting in high plasma concentrations in humans. Expand
Pharmacokinetics and pharmacodynamics of a recombinant human granulocyte colony-stimulating factor.
TLDR
The correlation between G-CSF clearance and peripheral neutrophil counts in the patients suggests that G- CSF receptor in bone marrow might work not only as a signal transducer for differentiation and proliferation of granulopoietic precurcer cells but as a regulator of G-csF levels in blood. Expand
CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes.
TLDR
Results indicate that vinorelbine metabolism is expected to be modulated by the drugs that are able to inhibit or induce CYP3A activity. Expand
Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): species differences among rats, monkeys and humans.
TLDR
The in vitro metabolic activities in rat bone marrow, spleen cells and peripheral leukocytes, which possess the G-CSF receptor, were determined and suggested that both saturable and nonsaturable processes are involved in NTG elimination. Expand
Cell cycle arrest and antitumor activity of pironetin and its derivatives.
TLDR
The cell cycle analysis revealed that pironetin arrested the cell cycle progression at the M-phase in a dose-dependent manner and will be the lead compound for a potential new antitumor drug. Expand
Pharmacokinetics of Amikacin and Cephalothin in Bedridden Elderly Patients
TLDR
Results suggest that in bedridden elderly patients decreased renal excretion of amikacin and cephalothin is related to decreased renal function and an increased Vd. Expand
Effect of pregnancy on the disposition of valproate in rats.
TLDR
The disposition of sodium valproate in pregnant rats was studied comparing with nonpregnant (control) rats and the tissue-to-plasma concentration ratio (Kp) of the brain was higher than that in the control rats, whereas the Kp values of the liver and and lung were lower than those in thecontrol rats. Expand
Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.
TLDR
The anti-angiogenic effect of licorice extract depended on the anti-tube formation effect of isoliquiritin, which inhibited tube formation from vascular endothelial cells in a concentration-dependent manner. Expand
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