The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.
- S. Kobayashi, S. Murray, D. Watson, D. Sesardic, D. Davies, A. Boobis
- Biology, ChemistryBiochemical Pharmacology
- 1 September 1989
Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.
- E. Fuse, H. Tanii, S. Kobayashi
- Biology, ChemistryCancer Research
- 1 August 1998
The results suggest that unusual pharmacokinetics of UCN-01 in humans could be due, at least in part, to its specifically high binding to alpha1-acid glycoprotein.
Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans.
- E. Fuse, H. Tanii, Y. Sugiyama
- Biology, ChemistryCancer Research
- 1 March 1999
The high degree of binding of UCN-01 to human AGP causes a reduction in the distribution and clearance, resulting in high plasma concentrations in humans.
Pharmacokinetics and pharmacodynamics of a recombinant human granulocyte colony-stimulating factor.
- T. Kuwabara, S. Kobayashi, Y. Sugiyama
- Biology, MedicineDrug metabolism reviews (Softcover ed.)
- 1 November 1996
The correlation between G-CSF clearance and peripheral neutrophil counts in the patients suggests that G- CSF receptor in bone marrow might work not only as a signal transducer for differentiation and proliferation of granulopoietic precurcer cells but as a regulator of G-csF levels in blood.
CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes.
- J. Kajita, T. Kuwabara, H. Kobayashi, S. Kobayashi
- Biology, ChemistryDrug Metabolism And Disposition
- 1 September 2000
Results indicate that vinorelbine metabolism is expected to be modulated by the drugs that are able to inhibit or induce CYP3A activity.
Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): species differences among rats, monkeys and humans.
- T. Kuwabara, Y. Kato, S. Kobayashi, H. Suzuki, Y. Sugiyama
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 December 1994
The in vitro metabolic activities in rat bone marrow, spleen cells and peripheral leukocytes, which possess the G-CSF receptor, were determined and suggested that both saturable and nonsaturable processes are involved in NTG elimination.
Effect of pregnancy on the disposition of valproate in rats.
- S. Kobayashi, K. Takai, T. Iga, M. Hanano
- Biology, MedicineJournal of Pharmacobio-Dynamics
- 1 September 1990
The disposition of sodium valproate in pregnant rats was studied comparing with nonpregnant (control) rats and the tissue-to-plasma concentration ratio (Kp) of the brain was higher than that in the control rats, whereas the Kp values of the liver and and lung were lower than those in thecontrol rats.
Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.
- S. Kobayashi, T. Miyamoto, I. Kimura, M. Kimura
- Biology, ChemistryBiological and Pharmaceutical Bulletin
- 15 October 1995
The anti-angiogenic effect of licorice extract depended on the anti-tube formation effect of isoliquiritin, which inhibited tube formation from vascular endothelial cells in a concentration-dependent manner.
Kinetic analysis of receptor-mediated endocytosis of G-CSF derivative, nartograstim, in rat bone marrow cells.
- T. Kuwabara, S. Kobayashi, Y. Sugiyama
- Biology, ChemistryAmerican Journal of Physiology
- 1 July 1996
To elucidate the mechanism of the receptor-mediated clearance of granulocyte colony-stimulating factor (G-CSF), we performed kinetic analyses of the receptor-mediated endocytosis (RME) processes…
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