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Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid*
Lysophosphatidic acid (LPA), together with sphingosine 1-phosphate, is a bioactive lipid mediator that acts on G-protein-coupled receptors to evoke multiple cellular responses, including Ca2+Expand
FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer
Pancreatic cancer has one of the highest mortalities among all malignancies and there is an urgent need for new therapy. This might be achieved by resolving the detailed biological mechanism, and inExpand
Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031.
Effects of bepridil on the depolarization-activated outward K(+) currents (I(out)) in rat atrial myocytes and the human cardiac K(+) (hKv1.5) channel current stably expressed in human embryonicExpand
Prophylactic excision of the gallbladder and bile duct for patients with pancreaticobiliary maljunction.
HYPOTHESIS Pancreaticobiliary maljunction (PBM) is a high-risk factor for biliary tract carcinogenesis because of a continuous reflux of pancreatic juice into the biliary tract. It remains to beExpand
Inhibition of human immunodeficiency virus (HIV-1) replication by synthetic oligo-RNA derivatives.
Several synthetic 2'-O-methyl-RNA oligomers and their derivatives have been evaluated for inhibitory effect against HIV-induced cytopathic effect and expression of the virus specific antigen inExpand
Isolation and structure of antipeptic ulcer diterpene from Thai medicinal plant.
A potent antipeptic ulcer substance, acyclic diterpene alcohol, was isolated from a Thai medicinal plant identified with Croton sublyratus KURZ. The structure was determined by the spectral data andExpand
Development of a minimal medium for Streptococcus mutans.
Abstract A minimal medium has been developed which can support good growth of Streptococcus mutans BHT and certain other strains. It is useful in solid as well as liquid forms.
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B)
Novel adenosine antagonists, 2-alkynyl-8-aryl-9-methyladenine derivatives, were synthesized as candidate hypoglycemic agents. These analogues were evaluated for inhibitory activity onExpand
A simple method for the quantification of famotidine in human plasma and urine by paired-ion high performance liquid chromatography.
A new method for the quantification of famotidine consists of a simple extraction procedure and paired-ion high performance liquid chromatography with ultraviolet detection. The method has goodExpand
Hepatitis B virus DNA integration frequently observed in the hepatocellular carcinoma DNA of hepatitis C virus-infected patients.
Human hepatitis B virus (HBV) and hepatitis C virus (HCV) are two major etiologic agents of chronic hepatitis, which is closely related to the development of hepatocellular carcinoma (HCC). WeExpand