S. Knöchel

Publications12
h-index12
Citations584
Highly Influential Citations45
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Bone morphogenetic protein 2 in the early development of Xenopus laevis
The temporal and spatial transcription patterns of the Xenopus laevis Bone morphogenetic protein 2 (BMP-2) gene have been investigated. Unlike the closely related BMP-4 gene, the BMP-2 gene is… Expand
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Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos.
A gene family encoding the fork head/HNF-3 domain has been identified in the South African clawed frog, Xenopus laevis. Screening of genomic DNA and gastrula stage derived cDNA libraries with a DNA… Expand
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POU‐V factors antagonize maternal VegT activity and β‐Catenin signaling in Xenopus embryos
VegT and β‐Catenin are key players in the hierarchy of factors that are required for induction and patterning of mesendoderm in Xenopus embryogenesis. By descending the genetic cascades, cells lose… Expand
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The POU Factor Oct-25 Regulates the Xvent-2B Gene and Counteracts Terminal Differentiation in Xenopus Embryos*
The Xvent-2B promoter is regulated by a BMP-2/4-induced transcription complex comprising Smad signal transducers and specific transcription factors. Using a yeast one-hybrid screen we have found that… Expand
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Sequence and expression of FoxB2 (XFD-5) and FoxI1c (XFD-10) in Xenopus embryogenesis
We report on the temporal and spatial expression pattern of two novel genes of the Xenopus fork head/winged helix family, xFoxB2 and xFoxI1c. xFoxB2 is activated at the late blastula stage and first… Expand
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Structural and functional analysis of the BMP-4 promoter in early embryos of Xenopus laevis
The Xenopus laevis BMP-4 gene shows an evolutionary conserved structure containing two coding exons and a leader exon. The transcripts which are detected after zygotic activation of the gene in… Expand
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XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos
The active form of the Xenopus X-box binding protein 1 (xXBP1) partially synergizes and partially antagonizes with BMP-4 signaling. xXBP1 overexpression inhibits mesoderm differentiation and… Expand
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Activin A induced expression of a <ce:italic>fork head</ce:italic> related gene in posterior chordamesoderm (notochord) of <ce:italic>Xenopus laevis</ce:italic> embryos
A gene family encoding the fork head/HNF-3 domain has been identified in the South African clawed frog, Xenopus laevis. Screening of genomic DNA and gastrula stage derived cDNA libraries with a DNA… Expand
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The Homeodomain Transcription Factor Xvent-2 Mediates Autocatalytic Regulation of BMP-4 Expression in XenopusEmbryos*
Like other genes of the transforming growth factor-β family, the BMP-4 gene is regulated by an autocatalytic loop. In Xenopus embryos this loop can be ectopically induced by injection of BMP-2 RNA.… Expand
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c-Jun (AP-1) activates BMP-4 transcription in Xenopus embryos
Zygotic expression of the BMP-4 gene in Xenopus embryos is regulated by an auto-regulatory loop. Since AP-1 is known as a mediator of auto-regulatory loops both in the case of the Drosophila dpp and… Expand
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