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Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatoryExpand
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Role of NRF2 in protection against hyperoxic lung injury in mice.
NRF2 is a transcription factor important in the protection against carcinogenesis and oxidative stress through antioxidant response element (ARE)-mediated transcriptional activation of several phaseExpand
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Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
We recently used positional cloning to identify the transcription factor Nrf2 (NF‐E2 related factor 2) as a susceptibility gene in a murine model of oxidant‐induced acute lung injury (ALI). NRF2Expand
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Nrf2 defends the lung from oxidative stress.
Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants, pro-oxidants,Expand
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Differential control of ventilation among inbred strains of mice.
The role genetic factors play in ventilatory control was examined by challenging eight inbred strains of mice to acute hypercapnia under normoxic and hypoxic conditions. Age-matched mice were exposedExpand
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Genetic influence on daily wheel running activity level.
This project was designed to determine the genetic (between-strain) and environmental (within-strain) variance in daily running wheel activity level in inbred mice. Five male and five female mice,Expand
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Identification of polymorphic antioxidant response elements in the human genome.
Single nucleotide polymorphisms (SNPs) in transcription factor binding sites (TFBSs) may affect the binding of transcription factors, lead to differences in gene expression and phenotypes andExpand
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Oxidants and the pathogenesis of lung diseases.
The increasing number of population-based and epidemiologic associations between oxidant pollutant exposures and cardiopulmonary disease exacerbation, decrements in pulmonary function, and mortalityExpand
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Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice.
RATIONALE The NF-E2 related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is essential for protection against oxidative injury and inflammation including hyperoxia-induced acute lungExpand
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Nrf2 protects against airway disorders.
Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor that regulates antioxidant response elements (AREs)-mediated expression of antioxidant enzyme andExpand
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