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Biofilms: an emergent form of bacterial life
- H. Flemming, J. Wingender, U. Szewzyk, P. Steinberg, S. Rice, S. Kjelleberg
- BiologyNature Reviews Microbiology
- 1 September 2016
The fundamental role of the biofilm matrix is considered, describing how the characteristic features of biofilms — such as social cooperation, resource capture and enhanced survival of exposure to antimicrobials — all rely on the structural and functional properties of the matrix.
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms
- Marie Allesen-Holm, K. B. Barken, T. Tolker-Nielsen
- Biology, EngineeringMolecular microbiology
- 1 February 2006
Experiments with P. aeruginosa strains indicated that the extracellular DNA is generated via a mechanism which is dependent on acyl homoserine lactone and Pseudomonas quinolone signalling, as well as on flagella and type IV pili.
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
A synthetic derivate of natural furanone compounds can act as a potent antagonist of bacterial quorum sensing and inhibited virulence factor expression in a mouse pulmonary infection model.
The genomic basis of trophic strategy in marine bacteria
- F. Lauro, D. McDougald, R. Cavicchioli
- Biology, Environmental ScienceProceedings of the National Academy of Sciences
- 15 September 2009
This work compares the genome sequences of two bacteria, Photobacterium angustum S14 and Sphingopyxis alaskensis RB2256, that serve as useful model organisms for copiotrophic and oligotrophic modes of life and relates the genomic features to trophic strategy for these organisms and defines their molecular mechanisms of adaptation.
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa
- N. Barraud, D. Hassett, S. Hwang, S. Rice, S. Kjelleberg, J. Webb
- Biology, EngineeringJournal of bacteriology
- 1 November 2006
It is demonstrated that exposure to SNP greatly enhanced the efficacy of antimicrobial compounds in the removal of established P. aeruginosa biofilms from a glass surface and combined exposure to both NO and antimicrobial agents may offer a novel strategy to control preestablished, persistent P. aerobicaerobic bacteria.
Animals in a bacterial world, a new imperative for the life sciences
- M. McFall-Ngai, M. Hadfield, J. Wernegreen
- BiologyProceedings of the National Academy of Sciences
- 7 February 2013
Recent technological and intellectual advances that have changed thinking about five questions about how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other’s genomes; how does normal animal development depend on bacterial partners; and how is homeostasis maintained between animals and their symbionts are highlighted.
Off the hook--how bacteria survive protozoan grazing.
Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal
- D. McDougald, S. Rice, N. Barraud, P. Steinberg, S. Kjelleberg
- BiologyNature Reviews Microbiology
Recent progress in this emerging field is reviewed and it is suggested that the merging of detailed molecular mechanisms with ecological theory will significantly advance understanding of biofilm biology and ecology.
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.
It is demonstrated that the furanone compound specifically represses expression of a PlasB-gfp reporter fusion without affecting growth or protein synthesis, indicating a general effect on target genes of the las quorum sensing circuit.
rpoB-Based Microbial Community Analysis Avoids Limitations Inherent in 16S rRNA Gene Intraspecies Heterogeneity
- I. Dahllöf, H. Baillie, S. Kjelleberg
- Medicine, BiologyApplied and Environmental Microbiology
- 1 August 2000
The frequency of 16S rDNA heterogeneity in bacteria isolated from the marine environment was assessed using bacterial isolates from the red alga Delisea pulchra and from the surface of a marine rock to prove the effectiveness of the gene for the RNA polymerase beta subunit (rpoB), which appears to exist in one copy only in bacteria.