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Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
An elevation in circulating serum uric acid is strongly associated with the development of hypertension and renal disease, but whether uric acid has a causal role or whether it simply indicatesExpand
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Reappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease.
An elevated uric acid level is associated with cardiovascular disease. Hyperuricemia is predictive for the development of both hypertension and coronary artery disease; it is increased in patientsExpand
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Serum uric acid and cardiovascular events in successfully treated hypertensive patients.
To determine whether pretreatment and/or in-treatment serum uric acid (SUA) is independently and specifically associated with cardiovascular events in hypertensive patients, we examined the 20-yearExpand
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Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolemia.
BACKGROUND Angiotensin II may contribute to atherogenesis by facilitating the proliferative and inflammatory response to hypercholesterolemia. This study determined, in a primate model ofExpand
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Hyperuricemia exacerbates chronic cyclosporine nephropathy.
BACKGROUND Hyperuricemia frequently complicates cyclosporine (CSA) therapy. The observation that longstanding hyperuricemia is associated with chronic tubulointerstitial disease and intrarenalExpand
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A new method of measuring renal function in conscious rats without the use of radioisotopes.
The purpose of the current experiment was to develop fast and accurate assays for measuring glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). An enzymatic method was developedExpand
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Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR.
In an earlier study, we found increased NO production and NO synthase (NOS) expression in renal and vascular tissues of prehypertensive and adult spontaneously hypertensive rats (SHR). This study wasExpand
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In vitro pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for AT2 receptors.
L-163,017 (6-[benzoylamino]-7-methyl-2-propyl-3-[[2'-(N-(3-methyl-1-butoxy) carbonylaminosulfonyl) [1,1']-biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine) inhibited specific 125I-[Sar1,Expand
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Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist.
L-754,142, (-)-N-(4-iso-propylbenzenesulfonyl)-alpha-(4-carboxyl-2-n-propy lphenoxy)-3,4- methylenedioxyphenylacetamide, is a potent nonpeptidyl endothelin antagonist (e.g., Ki: cloned human ETA =Expand
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Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension.
BACKGROUND We have recently demonstrated that prolonged hypobaric hypoxia can lead to a hematocrit-independent sustained arterial hypertension (HTN) in genetically normotensive Sprague-Dawley rats.Expand
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