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Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds.
TLDR
The results suggest that the 4-hydroxyl group of the A- phenyl ring and the B-phenyl ring of BPA derivatives are required for these hormonal activities, and substituents at the 3,5-positions of the phenyl rings and the bridging alkyl moiety markedly influence the activities. Expand
Drug-metabolizing ability of molybdenum hydroxylases.
TLDR
Drug-drug interactions associated with aldehyde oxidase and xanthine oxidoreductase are of potential clinical significance and the variation of the activity is described in this review. Expand
Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.
TLDR
TBBPA, TCBPA, TMBPA and DMBPA can act as thyroid hormone-disrupting agents, and TBBPA showed suppressive action on T3 (5 x 10(-8) M)-enhancement of Rana rugosa tadpole tail shortening. Expand
The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats.
TLDR
In vitro metabolism of permethrin and its hydrolysis products in rats was investigated, and PBAlc formed was oxidized to PBAld and PBAcid by the cytochrome P450 system in rats. Expand
Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A.
TLDR
The results suggest that TBBPA and TCBPA act as thyroid hormone agonists, as well as estrogens. Expand
Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens.
TLDR
Results suggest that a 4-hydroxyl group on the phenyl ring of benzophenone derivatives is essential for high hormonal activities, and the presence of other hydroxyl groups markedly alters these activities. Expand
Nuclear Hormone Receptor Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells
TLDR
The results suggest that PBDEs and their metabolites might have multiple endocrine-disrupting effects via nuclear hormone receptors, and para-HO-PBDEs, in particular, possess more potent receptor activities compared with those of the parent PB DEs and corresponding para-MeO-PB DEs. Expand
Characterization of steroid hormone receptor activities in 100 hydroxylated polychlorinated biphenyls, including congeners identified in humans.
TLDR
Results suggest that a large number of OH-PCBs might act as agonists and/or antagonists against ERα/β, AR and GR. Expand
Identification of prostatic-secreted proteins in mice by mass spectrometric analysis and evaluation of lobe-specific and androgen-dependent mRNA expression.
TLDR
An outlined view of mouse prostate secretion is presented, which should contribute to an understanding of the biological functions of the prostate gland, as well as the androgen dependency of prostate secretion. Expand
Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver
TLDR
The complex Dedrick plot with SSS from PXB mice is useful for predicting the plasma concentration–time curve in drug discovery, although there are some limitations. Expand
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