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Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
The upper respiratory tract is continually assaulted with harmful dusts and xenobiotics carried on the incoming airstream. Detection of such irritants by the trigeminal nerve evokes protectiveExpand
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Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction
BackgroundTaste receptor cells are responsible for transducing chemical stimuli into electrical signals that lead to the sense of taste. An important second messenger in taste transduction is IP3,Expand
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Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway
Rat taste buds contain three morphologically distinct cell types that are candidates for taste transduction. The physiologic roles of these cells are, however, not clear. Inositol 1,4,5‐triphosphateExpand
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Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25
BackgroundTaste receptor cells are responsible for transducing chemical stimuli from the environment and relaying information to the nervous system. Bitter, sweet and umami stimuli utilize G-proteinExpand
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ATP Signaling Is Crucial for Communication from Taste Buds to Gustatory Nerves
Taste receptor cells detect chemicals in the oral cavity and transmit this information to taste nerves, but the neurotransmitter(s) have not been identified. We report that adenosine 5′-triphosphateExpand
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Epithelial Na+ channel subunits in rat taste cells: Localization and regulation by aldosterone
Amiloride‐sensitive Na+ channels play an important role in transducing Na+ salt taste. Previous studies revealed that in rodent taste cells, the channel shares electrophysiological andExpand
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Taste receptor signalling – from tongues to lungs
  • S. Kinnamon
  • Biology, Medicine
  • Acta physiologica
  • 1 February 2012
Taste buds are the transducing endorgans of gustation. Each taste bud comprises 50–100 elongated cells, which extend from the basal lamina to the surface of the tongue, where their apical microvilliExpand
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FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.
The liver is an important integrator of nutrient metabolism, yet no liver-derived factors regulating nutrient preference or carbohydrate appetite have been identified. Here we show that the liverExpand
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Amiloride-sensitive channels in type I fungiform taste cells in mouse
BackgroundTaste buds are the sensory organs of taste perception. Three types of taste cells have been described. Type I cells have voltage-gated outward currents, but lack voltage-gated inwardExpand
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Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro.
Nasal trigeminal chemosensitivity in mice and rats is mediated in part by epithelial solitary chemoreceptor (chemosensory) cells (SCCs), but the exact role of these cells in chemoreception isExpand
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