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DA-1229, a novel and potent DPP4 inhibitor, improves insulin resistance and delays the onset of diabetes.
AIM To characterize the pharmacodynamic profile of DA-1229, a novel dipeptidyl peptidase (DPP) 4 inhibitor. MAIN METHODS Enzyme inhibition assays against DPP4, DPP8 and DPP9. Antidiabetic effectsExpand
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Candidate molecule for premature ejaculation, DA-8031: in vivo and in vitro characterization of DA-8031.
OBJECTIVES To evaluate the efficacy of DA-8031 against premature ejaculation, we performed in vitro and in vivo pharmacologic studies. METHODS We used a monoamine transporter binding affinityExpand
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Protective effects of acetyl-L-carnitine on neurodegenarative changes in chronic cerebral ischemia models and learning-memory impairment in aged rats
This study investigated the effects of acetyl-L-carnitine (ALC) in secondarily-induced cerebral chronic ischemia models using rats with permanent ligation of bilateral common carotid arteries (BCCL)Expand
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Rehabilitation nach Beugesehnenverletzungen an der Hand
ZusammenfassungHintergrundFortschritte in der Grundlagenforschung bezüglich Nahtmaterial, Nahtverfahren und Belastungsgrenzen unterstützen die Wahl der Behandlungsprotokolle nachExpand
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Nouvelle composition pour le traitement du reflux gastro-oesophagien
La presente invention concerne une nouvelle composition pour le traitement du reflux gastro-oesophagien (RGO). La composition pharmaceutique selon la presente invention est une nouvelle compositionExpand
New Synthesis of Sestamibi and Comparison of Stability of Its Formulation
Purpose: Ascorbic acid us known to act as an antioxidant. Therefore, it can be used in increasing the efficiency of radiochemical labeling of Technetium-99m setamibi by inhibition of oxidation of atExpand
Derives de pyrazolopyrimidinone utiles pour traiter l'impuissance
La presente invention concerne des derives de pyrazolopyrimidinone de formule (1), leur procede de preparation et des compositions pharmaceutiques contenant lesdits derives. Ces composes sontExpand
Composition destinée à prévenir ou à traiter l'obésité ou les maladies métaboliques d'origine lipidique
Cette invention concerne une composition pharmaceutique destinee a prevenir ou a traiter l'obesite ou une maladie metabolique d'origine lipidique et un aliment destine a ameliorer ou a prevenirExpand