• Publications
  • Influence
Chemical modification of siRNAs to improve serum stability without loss of efficacy.
Development of RNA interference as a novel class of therapeutics requires improved pharmacokinetic properties of short interfering RNA (siRNA). To confer enhanced serum stability to Sur10058, aExpand
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MicroRNA miR-199a* Regulates the MET Proto-oncogene and the Downstream Extracellular Signal-regulated Kinase 2 (ERK2)*
MicroRNAs (miRNAs) constitute a class of small noncoding RNAs that play important roles in a variety of biological processes including development, apoptosis, proliferation, and differentiation. HereExpand
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H-Ras-specific Activation of Rac-MKK3/6-p38 Pathway
Human tumors frequently exhibit constitutively activated Ras signaling, which contributes to the malignant phenotype. Mounting evidence suggests unique roles of the Ras family members, H-Ras, N-RasExpand
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Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: the role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression.
  • S. Kim, H. Chung, J. Cho
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 May 1996
The modulation of CCl4-induced hepatotoxicity in response to alkyl sulfides and alkyl ethers including allyl disulfide (ADS), allyl sulfide (AS), allyl ether (AE), propyl disulfide (PDS), propylExpand
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Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects.
Cytochrome P450 2E1 (P450 2E1) is active in both the detoxification and activation of small organic molecules. The effects of 2-(allylthio)pyrazine (2-AP) on P450 2E1-catalytic activity and theExpand
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Inhibition of lipopolysaccharide-induced I-kappaB degradation and tumor necrosis factor-alpha expression by dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB): minor
AIMS/BACKGROUND Dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) is active against a variety of hepatotoxins and has been used as a curative agent for patientsExpand
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Piperine effects on the expression of P4502E1, P4502B and P4501A in rat.
1. Treatment of rat with piperine (PIP) (1.4 mmol/kg, 3 days ip injections) resulted in an approximate two-fold increase in total liver microsomal P450 content relative to that in uninduced animals.Expand
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Chemopreventive effects of 2-(Allylthio)pyrazine
  • N. Kim, S. Kim
  • Chemistry, Medicine
  • Archives of pharmacal research
  • 1 April 1999
A series of organosulfur compounds were synthesized with the aim of developing chemopreventive compounds active against hepatotoxicity and chemical carcinogenesis. 2-(Allylthio) pyrazine (2-AP) wasExpand
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Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya, Yb1, Yb2, Yc1, and Yc2 gene expression by oltipraz: possible role in radioprotection.
Previous studies have shown that radiation in combination with oltipraz enhances hepatic microsomal epoxide hydrolase expression. The effects of gamma-ray radiation exposure in combination withExpand
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Enhanced Anti‐tumour Effects of Acriflavine in Combination with Guanosine in Mice
  • S. Kim, C. W. Kim, +4 authors Y. Han
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1 February 1997
The anti‐tumour activity of acriflavine in combination with guanosine has been evaluated in solid or ascitic tumour‐implanted animal models. Guanosine is known to potentiate the anti‐tumour effectsExpand
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