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Clp P represents a unique family of serine proteases.
TLDR
The sequences around the active site residues suggest that Clp P represents a unique class of serine protease, which is likely to involve an intermolecular autocatalytic cleavage reaction in bacteria and in lower eukaryotes. Expand
TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression*
TLDR
Characterization of a second human tankyrase, TANK2, is reported, which can also interact with TRF1 but has properties distinct from those of TANK1, and which caused rapid cell death when highly overexpressed. Expand
Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes.
TLDR
Results demonstrate 125I-[D-Tyr6,betaAla11,Phe13,Nle14]bombesin-(6-1 4) is a unique ligand with high affinity for all subtypes of bombesin receptors. Expand
Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumor cells.
TLDR
The results suggest that KML-C is a novel lectin related to the cytotoxicity of Korean mistletoe, and that its cytotoxic activity against tumor cells is due to apoptosis mediated by Ca2+/Mg2+ -dependent endonucleases. Expand
Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza.
TLDR
The effects of three different tanshinone pigments from Salvia miltiorrhiza on IL-12 production in mouse macrophages and on IFN-gamma production in lymph node cells are investigated to suggest a possible use of tansinones in the treatment of immunological diseases dominated by Th1-derived cytokine responses. Expand
Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma
TLDR
OxLDL-mediated suppression of the IL-12 production from LPS-activated mouse macrophages may, at least in part, involve both inhibition of the NF-kappaB-DNA interactions and physical interactions between NF- kappaB and PPAR-gamma. Expand
p53 mutations in solar keratoses.
TLDR
The results suggest that sunlight can cause mutations of p53 gene and that p 53 gene mutations may play an important role in skin carcinogenesis. Expand
Serum VEGF levels in acute ischaemic strokes are correlated with long‐term prognosis
TLDR
This investigation investigated whether serum vascular endothelial growth factor levels in acute‐stage ischaemic stroke patients with small vessel disease or large vessel disease are correlated with long‐term prognoses, based on the difference in NIH Stroke Scale (NIHSS) scores between acute and chronic stages. Expand
Extremely Thermostable Serine-type Protease from Aquifex pyrophilus
TLDR
A gene encoding a serine-type protease has been cloned from Aquifex pyrophilus using a sequence tag containing the consensus sequence of proteases as a probe, suggesting that it is one of the most heat-stable proteases. Expand
T cell lymphoma in transgenic mice expressing the human Hsp70 gene.
TLDR
These results provide the first experimental evidence that hsp70 is involved in the tumorigenesis of T cells most likely through the blockage of apoptotic signals. Expand
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