• Publications
  • Influence
A wavelet-based method for action potential detection from extracellular neural signal recording with low signal-to-noise ratio
  • Kyung Hwan Kim, S. Kim
  • Computer Science, Medicine
  • IEEE Transactions on Biomedical Engineering
  • 22 July 2003
TLDR
An action potential detector based on a prudent combination of wavelet coefficients of multiple scales is proposed and its performance for neural signal recording with varying degrees of similarity between signal and noise is demonstrated. Expand
Neural spike sorting under nearly 0-dB signal-to-noise ratio using nonlinear energy operator and artificial neural-network classifier
  • Kyung Hwan Kim, S. Kim
  • Computer Science, Medicine
  • IEEE Transactions on Biomedical Engineering
  • 1 October 2000
TLDR
The superior detection ability facilitates the collection of a training set under lower SNR than that of the methods which employ simple amplitude thresholding, so that the statistical characteristics of the input vectors can be better represented in the neural-network classifier. Expand
Biphasic electric current stimulates proliferation and induces VEGF production in osteoblasts.
TLDR
BEC increases cell proliferation and induces the production of VEGF and real-time RT-PCR and ELISA demonstrated that vascular endothelial growth factor (VEGF) was markedly up-regulated by BEC. Expand
Low-density neuronal networks cultured using patterned poly-l-lysine on microelectrode arrays
  • S. Jun, M. Hynd, +4 authors S. Kim
  • Biology, Medicine
  • Journal of Neuroscience Methods
  • 15 March 2007
TLDR
Application of DNQX, an AMPA antagonist, blocked all spontaneous activity, suggesting that the activity is excitatory and mediated through glutamate receptors. Expand
Novel effect of biphasic electric current on in vitro osteogenesis and cytokine production in human mesenchymal stromal cells.
TLDR
Findings reveal that BEC is involved in the osteoblast differentiation of hMSCs through enhancement of cell proliferation and modulation of the local endocrine environment through VEGF and BMP-2 induction through the activation of MAPK and p38 and the calcium channel. Expand
Selectivity of Neuromodulatory Projections from the Basal Forebrain and Locus Ceruleus to Primary Sensory Cortices
TLDR
Using a dual retrobead tracing technique along with optogenetic stimulation, anatomic and functional differences in the way cholinergic BF neurons and noradrenergic LC neurons project into primary sensory cortices are identified. Expand
Monolithic Encapsulation of Implantable Neuroprosthetic Devices Using Liquid Crystal Polymers
TLDR
A monolithic encapsulation platform for neuroprosthetic devices using liquid crystal polymers (LCPs), which have a very low degree of moisture absorption and a fusion bondable interface, and showed that LCP encapsulation was superior and more reliable in PBS than polyimide and parylene-C encapsulations. Expand
Enhanced infrared neural stimulation using localized surface plasmon resonance of gold nanorods.
TLDR
An advanced optical activation of neural tissues is demonstrated using pulsed infrared light and plasmonic gold nanorods, which can increase a neural responsivity and lower a threshold stimulation level significantly, thereby reducing a requisite radiant exposure and the concern of tissue damage. Expand
A Flexible Depth Probe Using Liquid Crystal Polymer
  • Sung Eun Lee, S. Jun, +6 authors S. Kim
  • Materials Science, Medicine
  • IEEE Transactions on Biomedical Engineering
  • 14 June 2012
TLDR
The first attempt to use a flexible material, liquid crystal polymer (LCP), as a substrate for a depth-type neural probe is reported, offering a controllable stiffness vs. flexibility and compatibility with thin-film processes in addition to its inherent characteristics such as high reliability and biocompatibility. Expand
Spectrum measurement of fast optical signal of neural activity in brain tissue and its theoretical origin
TLDR
The results verified that observed transient optical responses (tORs) are associated with neural activity by showing that the following: tORs were concurrent and correlated with local field potentials (LFPs); tORS disappeared following tetrodotoxin application; and t ORs were reproducibly observed across preparations. Expand
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