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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led… Expand
SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas
Lineage-survival oncogenes are activated by somatic DNA alterations in cancers arising from the cell lineages in which these genes play a role in normal development. Here we show that a peak of… Expand
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.
- T. Nobukuni, M. Joaquin, +9 authors G. Thomas
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 4 October 2005
During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the primordial amino… Expand
Skp2 regulates Myc protein stability and activity.
- S. Kim, A. Herbst, Kathryn A Tworkowski, S. Salghetti, W. Tansey
- Medicine, Biology
- Molecular cell
- 1 May 2003
Myc is an oncoprotein transcription factor that plays a prominent role in cancer. Like many transcription factors, Myc is an unstable protein that is destroyed by ubiquitin (Ub)-mediated proteolysis.… Expand
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell types, including primary and nondividing cells, we are developing lentiviral short hairpin RNA (shRNA) libraries… Expand
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Aberrant activation of the canonical WNT/β-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated β-catenin activity… Expand
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
- Lauren L C Marotta, V. Almendro, +25 authors K. Polyak
- Biology, Medicine
- The Journal of clinical investigation
- 1 July 2011
Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display variable sensitivity to therapeutics and may play different roles in progression. We previously characterized… Expand
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent… Expand
Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene
The karyotypic chaos exhibited by human epithelial cancers complicates efforts to identify mutations critical for malignant transformation. Here we integrate complementary genomic approaches to… Expand
COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50–70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation… Expand