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Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1
Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are found in the perisynaptic region of the postsynaptic membrane.Expand
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TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord
Neuropathic pain and allodynia may arise from sensitization of central circuits. We report a mechanism of disinhibition-based central sensitization resulting from long-term depression (LTD) ofExpand
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PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility
Phosphatidylinositol 3-kinase (PI3K) has been implicated in synaptic plasticity and other neural functions in the brain. However, the role of individual PI3K isoforms in the brain is unclear. WeExpand
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Oxytocin mediates stress‐induced analgesia in adult mice
As a neurohormone and as a neurotransmitter, oxytocin has been implicated in the stress response. Descending oxytocin‐containing fibres project to the dorsal horn of the spinal cord, an areaExpand
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Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
Long-term treatments to ameliorate peripheral neuropathic pain that includes mechanical allodynia are limited. While glial activation and altered nociceptive transmission within the spinal cord areExpand
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TRPC3 Channel Underlies Cerebellar Long-Term Depression
  • S. Kim
  • Biology, Medicine
  • The Cerebellum
  • 14 February 2013
Cerebellar long-term depression (LTD) is induced by repetitive pairing of both synaptic inputs provided by climbing fibers (CFs) and parallel fibers (PFs), especially when CF stimulation followed byExpand
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Lobule‐specific membrane excitability of cerebellar Purkinje cells
Non‐technical summary  Cerebellar vermis consists of 10 lobules, and each lobule receives different sensory information. Afferent inputs are integrated in cerebellar Purkinje cells (PCs) which areExpand
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Inhibition of apamin-sensitive K+ current by hypoxia in adult rat adrenal chromaffin cells
The effect of hypoxia on small-conductance Ca2+-activated K+ current was investigated in a study of adult rat adrenomedullary chromaffin cells (AMCs), which were maintained in short-term culture. TheExpand
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Ubiquitous Plasticity and Memory Storage
To date, most hypotheses of memory storage in the mammalian brain have focused upon long-term synaptic potentiation and depression (LTP and LTD) of fast glutamatergic excitatory postsynaptic currentsExpand
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RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer's disease animal model
The receptor for advanced glycation end products (RAGE) is a multiligand cell surface receptor, and amyloid P peptide (Aβ) is one of the ligands for RAGE. Because RAGE is a transporter of Aβ from theExpand
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