• Publications
  • Influence
Dual Role of Inflammatory Stimuli in Activation-induced Cell Death of Mouse Microglial Cells
  • Jongseok Lee, J. Hur, +6 authors K. Suk
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 31 August 2001
Evidence is presented that interferon regulatory factor-1 (IRF-1) and caspase-11 are the essential molecules in activation-induced cell death of microglial cells and that LPS/IFNγ not only induced the production of cytotoxic NO through IRf-1 but also initiated the NO-independent apoptotic pathway through the induction of casp enzyme-11. Expand
Neuroprotective effects of the cyanidin-3-O-β-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia
Compared with the control group, C3G had neuroprotective effects on the PC12 cells exposed to hydrogen peroxide in vitro and on cerebral ischemic damage in vivo. Expand
Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds.
It is suggested that the zebrafish system is a novel alternative to mammalian models, with several advantages including the rapidity, cost-effectiveness, and physiological relevance, in screening and evaluating the putative melanogenic regulatory compounds. Expand
Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-κB and JNK activations in microglia cells
The results suggest that chrysin may act as a potential therapeutic agent for various neurodegenerative diseases involving neuroinflammation. Expand
Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia
  • Heasuk Lee, Young Ok Kim, +6 authors K. Suk
  • Medicine
  • FASEB journal : official publication of the…
  • 1 October 2003
The results indicate that wogonin exerts its neuroprotective effect by inhibiting microglial activation, which is a critical component of pathogenic inflammatory responses in neurodegenerative diseases. Expand
Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models
Results indicate that ME has neuroprotective effects in in vitro and in vivo PD models, and that it may be useful in preventing or treating PD. Expand
Neurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathway.
Neuritogenic effects resulting from spicatoside A may be involved in TrkA activation in the treatment of Alzheimer's disease. Expand
Induction of caspase‐11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen‐activated protein kinase pathway
The expression of caspase‐11 was strongly induced at both mRNA and protein levels by inflammatory stimuli such as lipopolysaccharide (LPS), interferon‐γ, and tumor necrosis factor‐α in C6 rat glial cells as well as primary astrocytes. Expand
High dosage sildenafil induces hearing impairment in mice.
It is demonstrated that high-dose and long-term sildenafil administration can induce hearing impairment in mice, and hearing loss following the ingestion of this drug is reported in one male patient. Expand
6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection
6-Shogaol showed significant neuroprotective effects in vivo in transient global ischemia via the inhibition of microglia, suggesting that 6-shogaol is an effective therapeutic agent for treating neurodegenerative diseases. Expand