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Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.
Findings implicate OX(2)R in the NAc in the nucleus accumbens in mediating the reinforcing effects of ethanol and suggest a potential therapeutic target for the treatment of ethanol-use disorders.
A Very Long Embargo: Journal Choice Reveals Active Non-Compliance with Funder Open Access Policies by Australian and Canadian Neuroscientists
It is found that the implementation of Australian and Canadian funder open access policies in 2012/2013 and 2015 did not reduce the number of publications in non-compliant journals, and scientific output in all publication types increased with the greatest growth in immediate open access journals.
Orexin‐1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue‐induced reinstatement of ethanol‐seeking in iP rats
It is suggested that OX1 receptors located in the prelimbic cortex and ventral tegmental area are part of a circuit driving cue‐mediated ethanol‐seeking behaviour.
How contexts promote and prevent relapse to drug seeking
There is significant functional compartmentalization and segregation within these structures during reinstatement and extinction of drug seeking that parallels their anatomical segregation into circuits and channels, and a key challenge is to recognize this complexity, understand how these circuits andannels are organized, as well as understand how different modes of activity of ensembles of neurons within them promote abstinence or relapse to drug seeking.
Article Processing Charge Hyperinflation and Price Insensitivity: An Open Access Sequel to the Serials Crisis
  • S. Khoo
  • Economics
    LIBER Quarterly: The Journal of the Association…
  • 9 May 2019
Open access publishing has frequently been proposed as a solution to the serials crisis, which involved unsustainable budgetary pressures on libraries due to hyperinflation of subscription costs. The
Orexin/Hypocretin Based Pharmacotherapies for the Treatment of Addiction: DORA or SORA?
The question of whether to use a DORA or single orexin receptor antagonist (SORA) for the treatment of addiction is a key question that will need to be answered in order to maximize the clinical utility of orexIn receptor antagonists.
The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking
The results indicate that TCS1102 has no substantial effect on motivation for nicotine seeking following chronic self-administration and no effect after shorter periods of intake, suggesting that Orexin receptor antagonists may have little clinical utility against nicotine addiction.
Dopamine ‘ups and downs’ in addiction revisited
There is little evidence to suggest peer reviewer training programmes improve the quality of reviews
In little more than a year a number of peer reviewer training programmes have launched, promising to help early-career researchers learn how to do peer review, review more efficiently, and connect
Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding
These data are the first to show a role of mGluR5 in the context-dependent expression of appetitive Pavlovian conditioned responding, with a topographically defined arrangement of m GluR 5 in the BLA being particularly important for context-based responding to a discrete, appetitive cue.