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Adenoviral mediated gene transfer of PDGF‐B enhances wound healing in type I and type II diabetic wounds
Adenoviral‐PDGF‐B treatment significantly enhanced epithelial gap closure in db/db, streptozotocin, and nonobese NOD/Ltj mice as compared to diabetic phosphate buffered saline solution or Ad LacZ controls. Expand
Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection
It is reported that vaccination against phage virions represents a potential therapeutic strategy for the prevention of infections by antibiotic-resistant Pa, and the findings may have broad utility and impact beyond the pathophysiology of chronic wound infections. Expand
Regenerative Wound Healing: The Role of Interleukin-10.
IL-10 has been demonstrated to be critical in the fetus' intrinsic ability to heal without scars, and, further, can induce scarless healing in postnatal tissue, and holds significant potential as an anti-scarring therapeutic. Expand
The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing.
Advances in characterization of the EPC biology and enhancement of EPC functions are required and in vitro culture conditions should be optimized to mimic the in vivo milieu to fully characterize the biological function and contribution of E PCs to postnatal vasculogenesis. Expand
A Quality-Improvement Collaborative Project to Reduce Pressure Ulcers in PICUs
BACKGROUND AND OBJECTIVE: Pediatric patients are at risk for developing pressure ulcers (PUs) and associated pain, infection risk, and prolonged hospitalization. Stage III and IV ulcers are serious,Expand
Fetoscopic Open Neural Tube Defect Repair: Development and Refinement of a Two-Port, Carbon Dioxide Insufflation Technique.
Fetoscopic open neural tube defect repair does not appear to increase maternal-fetal complications as compared with repair by hysterotomy, allows for vaginal delivery, and may reduce long-term maternal risks. Expand
Permissive environment in postnatal wounds induced by adenoviral‐mediated overexpression of the anti‐inflammatory cytokine interleukin‐10 prevents scar formation
Overexpression of IL‐10 in postnatal wounds results in a permissive environment for scarless wound repair, possibly by replicating a fetal wound environment. Expand
The Role of Stem Cells in Wound Angiogenesis.
Stem-cell-based therapy holds significant potential as a strategy for therapeutic angiogenesis in the care of patients with chronic nonhealing wounds, and is being conducted to develop effective delivery routes. Expand
Chemokine Involvement in Fetal and Adult Wound Healing.
Fetal wounds heal with a regenerative phenotype that is indistinguishable from surrounding skin with restored skin integrity, a benchmark for postnatal wound healing, which can serve as a roadmap to recapitulating regenerative repair in adult wounds. Expand
Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells
It is concluded that topical application of BM‐derived SPCs may represent an effective strategy for the treatment of chronic diabetic wounds through indirect mechanisms which lead to enhanced vascularization rather than through direct participation and incorporation into tissue. Expand