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Malignant gliomas in adults.
Approximately 5% of patients with malignant gliomas have a family history of gliomas. Some of these familial cases are associated with rare genetic syndromes, such as neurofibromatosis types 1 and 2,… Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
- G. Gabriely, T. Wurdinger, +4 authors A. Krichevsky
- Biology, Medicine
- Molecular and Cellular Biology
- 30 June 2008
ABSTRACT Substantial data indicate that microRNA 21 (miR-21) is significantly elevated in glioblastoma (GBM) and in many other tumors of various origins. This microRNA has been implicated in various… Expand
Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma
Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including dependence on common lineage-restricted pathways, is unclear. We observe… Expand
Transdifferentiation of glioblastoma cells into vascular endothelial cells
- Yasushi Soda, T. Marumoto, +8 authors I. Verma
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 24 January 2011
Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive combination therapies and anti-VEGF therapies. To assess the resistance mechanism to anti-VEGF therapy, we… Expand
Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial.
IMPORTANCE Glioblastoma is the most devastating primary malignancy of the central nervous system in adults. Most patients die within 1 to 2 years of diagnosis. Tumor-treating fields (TTFields) are a… Expand
Bevacizumab for recurrent malignant gliomas
Background: Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor, may have activity in recurrent malignant gliomas. At recurrence some patients appear to develop… Expand
Development of NG2 neural progenitor cells requires Olig gene function
- K. Ligon, S. Kesari, +6 authors D. Rowitch
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 16 May 2006
In the adult central nervous system, two distinct populations of glial cells expressing the chondroitin sulfate proteoglycan NG2 have been described: bipolar progenitor cells and more differentiated… Expand
Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors.
Glioblastoma, the most malignant type of primary brain tumor, is one of the solid cancers where cancer stem cells have been isolated, and studies have suggested resistance of those cells to… Expand
Human glioma growth is controlled by microRNA-10b.
MicroRNA (miRNA) expression profiling studies revealed a number of miRNAs dysregulated in the malignant brain tumor glioblastoma. Molecular functions of these miRNAs in gliomagenesis are mainly… Expand