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Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.
It is shown that neutralization level is highly predictive of immune protection, and an evidence-based model of SARS-CoV-2 immune protection that will assist in developing vaccine strategies to control the future trajectory of the pandemic is provided.
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
- L. K. Mackay, Angus T Stock, T. Gebhardt
- Biology, MedicineProceedings of the National Academy of Sciences
- 16 April 2012
It is demonstrated that long-lived intraepithelial CD103+CD8+ TRM cells can be generated and survive in the absence of in situ antigen recognition and provide a powerful means of achieving immune protection against peripheral infection.
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies.
Key ADE mechanisms are described and mitigation strategies for SARS-CoV-2 vaccines and therapies in development are discussed and recently published data is outlined to evaluate the risks and opportunities for antibody-based protection against Sars-Cov-2.
Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost
This data indicates that reversion to wild type can occur following transmission to MHC-mismatched hosts in the absence of cytotoxic T-lymphocyte (CTL) pressure, due to the reduced fitness of the escape mutant virus.
Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells
A multipronged approach was undertaken to investigate which molecules are necessary for pAg detection by Vγ9Vδ2 T cells and the top candidate molecule identified in the genome-wide screen was butyrophilin 2A1 (BTN2A1), a molecule distinct from, but related to, BTN3A1.
Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies
It is concluded that there is a remarkable degree of cross-reactivity of influenza-specific ADCC Abs in seropositive humans, which could lead to improved influenza vaccines.
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
It is indicated that SARS-CoV-2 immunity after infection might be transiently protective at a population level and might require greater immunogenicity and durability than natural infection to drive long-term protection.
Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus
- S. Kent, A. Zhao, S. Best, Jenalle D. Chandler, D. Boyle, I. Ramshaw
- Biology, MedicineJournal of Virology
- 1 December 1998
These studies suggest a safe strategy for the enhanced generation of T-cell-mediated protective immunity to HIV-1, and a consecutive immunization strategy involving priming with DNA and boosting with rFPV vaccines encoding common HIV- 1 antigens is evaluated.
Immunological dysfunction persists for 8 months following initial mild-moderate SARS-CoV-2 infection
An elevated diffuse serum inflammatory cytokine profile in symptomatic long COVID subjects that was maintained at 8 months post-infection and was not observed in asymptomatic COVID-19 survivors is found.
Antibody-Dependent Cellular Cytotoxicity Is Associated with Control of Pandemic H1N1 Influenza Virus Infection of Macaques
It is shown that seasonal infection of influenza-naïve Indian rhesus macaques with A/Kawasaki/173/2001 (sH1N1) virus induces antibodies capable of binding the hemagglutinin of both the homologous seasonal virus and the antigenically divergent A/California/04/2009 strain in the absence of detectable H1N 1pdm-specific neutralizing antibodies.