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The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.
BACKGROUND & AIMS Prolyl and asparaginyl hydroxylases are key oxygen-sensing enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the hypoxia inducible factor 1… Expand
American Journal of Physiology: Gastrointestinal and Liver Physiology American Journal of Physiology: Heart and Circulatory Physi- QlQgY American Journal of Physiology: Regulatory, Integrative and…
s Invited for Fourth Annual Workshop on PULMONARY PHYSIOLOGY AND FUNCTlON TESTlNG IN SMALL LABORATORY ANI Satellite Conference to the Annual Meeting of the AMERICAN THORACIC SOCIETY
The autonomic nervous system and inflammatory bowel disease
Crohn's disease and ulcerative colitis, collectively known as inflammatory bowel disease (IBD), are chronic, recurring, inflammatory conditions of the intestine. The precise mechanisms underlying the… Expand
Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease.
- P. Hegyi, J. Maléth, J. Walters, A. F. Hofmann, S. Keely
- Physics, Medicine
- Physiological reviews
- 1 October 2018
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid to… Expand
Epidermal growth factor chronically upregulates Ca2+‐dependent Cl− conductance and TMEM16A expression in intestinal epithelial cells
Key points • Cl− secretion, the predominant driving force for fluid secretion in the intestine, can be dysregulated in conditions of disease, such as cystic fibrosis. • We have previously shown… Expand
Physiological concentrations of bile acids down‐regulate agonist induced secretion in colonic epithelial cells
- N. Keating, M. S. Mroz, +4 authors S. Keely
- Biology, Medicine
- Journal of cellular and molecular medicine
- 1 August 2009
In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl− and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the… Expand
Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon.
- J. Ward, Natalia K Lajczak, +9 authors S. Keely
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 30 March 2017
Ward JB, Lajczak NK, Kelly OB, O'Dwyer AM, Giddam AK, Ní Gabhann J, Franco P, Tambuwala MM, Jefferies CA, Keely S, Roda A, Keely SJ. Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory… Expand
The Farnesoid X Receptor: Good for BAD
Diarrhea is a feature of several chronic intestinal disorders that are associated with increased delivery of bile acids into the colon. Although the prevalence of bile acid diarrhea is high,… Expand
New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid.
- F. Májer, Ruchika Sharma, +9 authors J. Gilmer
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
We have prepared a new panel of 23 BA derivatives of DCA, chenodeoxycholic acid (CDCA) and lithocholic acid (LCA) in order to study the effect of dual substitution with 3-azido and 24-amidation,… Expand
Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis
Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) is a major cause of cystic fibrosis (CF), one of the most common inherited childhood diseases.… Expand