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Hetero-dimerization of serotonin 5-HT(2A) and dopamine D(2) receptors.
TLDR
The results suggest that these regions of 5-HT(2A)R and D(2)R may be involved in the interaction between these two proteins, and the influence of specific receptor ligands on the dimerization processes is estimated.
Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73
TLDR
A detailed characterization of the interaction of Mdm2 and Mdmx with the TA domains of p63 and p73 is presented and for the first time, the affinities of these interactions are determined.
Comparison of protein precipitation methods for various rat brain structures prior to proteomic analysis
TLDR
It was found that for four of the rat brain structures, precipitation with chloroform/methanol and acetone delivered the highest protein recovery for top‐down proteomic analysis; however, TCA precipitation resulted in good protein separation and the highest number of protein spots in 2‐DE.
Effect of chronic mild stress and imipramine on the proteome of the rat dentate gyrus
J. Neurochem. (2010) 113, 848–859.
cAMP Receptor Protein from Escherichia coli as a Model of Signal Transduction in Proteins – A Review
TLDR
The most sophisticated spectroscopic techniques, other techniques frequently used in structural biochemistry, and site-directed mutagenesis have been used to investigate the details of cAMP-mediated allosteric control over CRP conformation and activity as a transcription factor.
On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53
TLDR
It is shown that the biochemical mode of action of 1 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53.
Diverse impact of xeno-free conditions on biological and regenerative properties of hUC-MSCs and their extracellular vesicles
TLDR
The results show that proliferation, differentiation, phenotype stability, and cytokine secretion by UC-MSCs vary depending on the type of xeno-free media, which may be explained by elevated concentration of several pro-cardiogenic and pro-angiogenic microRNAs present in the EVs.
Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone
TLDR
Comparative proteomic analysis of rat cerebral cortex following chronic administration of clozapine and risperidone observed significant changes in the expression of cytoskeletal, synaptic, and regulatory proteins caused by both antipsychotics.
The Nucleocapsid Protein of Human Coronavirus NL63
TLDR
Surprisingly, analysis of the subcellular localization of the N protein of HCoV-NL63 revealed that, differently than homologous proteins from other coronaviral species except for SARS-CoV, it is not present in the nucleus of infected or transfected cells.
Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
TLDR
The presented data show a novel role of MCPIP1 in modulating insulin sensitivity in adipocytes, and demonstrate that M CPIP1 is an important regulator of adipogenesis and adipocyte metabolism.
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