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Orchestrated transcription of key pathways in Arabidopsis by the circadian clock.
This study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote. Expand
Reciprocal Regulation Between TOC1 and LHY/CCA1 Within the Arabidopsis Circadian Clock
It is shown that both proteins bind to a region in the TOC1 promoter that is critical for its clock regulation, and these interactions form a loop critical for clock function inArabidopsis. Expand
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation. Expand
The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila
Cryb flies are rhythmic in constant darkness, correlating with robust PER and TIM cycling in certain pacemaker neurons, and is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Expand
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.
The Drosophila CLOCK protein was shown to induce transcription of the circadian rhythm genes period and timeless, and PERIOD and TIMELESS proteins blocked dCLOCK's ability to transactivate their promoters via the E-box. Expand
Overlapping and Distinct Roles of PRR7 and PRR9 in the Arabidopsis Circadian Clock
- E. M. Farré, S. Harmer, F. Harmon, M. Yanovsky, S. Kay
- Biology, Medicine
- Current Biology
- 11 January 2005
It is proposed that the Arabidopsis circadian oscillator is composed of several interlocking positive and negative feedback loops, a feature of clock regulation that appears broadly conserved between plants, fungi, and animals. Expand
FKF1 and GIGANTEA Complex Formation Is Required for Day-Length Measurement in Arabidopsis
The FKF1-GI complex forms on the CO promoter in late afternoon to regulate CO expression, providing a mechanistic view of how the coincidence of light with circadian timing regulates photoperiodic flowering. Expand
The ELF4-ELF3-LUX Complex Links the Circadian Clock to Diurnal Control of Hypocotyl Growth
The evening complex underlies the molecular basis for circadian gating of hypocotyl growth in the early evening, and mutations in PIF4 and/or PIF5 are epistatic to the loss of the ELF4–ELF3–LUX complex, suggesting that regulation of Pif4 and PIF 5 is a crucial function of the complex. Expand
FKF1 F-Box Protein Mediates Cyclic Degradation of a Repressor of CONSTANS in Arabidopsis
It is demonstrated here that FKF1 controls the stability of a Dof transcription factor, CYCLING DOF FACTOR 1 (CDF1), and CDF1 protein is more stable in fkf1 mutants. Expand
Suprachiasmatic nucleus: cell autonomy and network properties.
The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances their precision. Expand