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The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis
Meiosis comprises a pair of specialized nuclear divisions that produce haploid germ cells. To accomplish this, sister chromatids must segregate together during the first meiotic division (meiosis I),Expand
Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin
Recruiting the Components for Cell Division A complete chromosome set must be apportioned to each daughter cell during cell division. A number of molecular mechanisms check that chromosome pairs orExpand
Shugoshin collaborates with protein phosphatase 2A to protect cohesin
Sister chromatid cohesion, mediated by a complex called cohesin, is crucial—particularly at centromeres—for proper chromosome segregation in mitosis and meiosis. In animal mitotic cells,Expand
Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.
Fission yeast shugoshin Sgo1 is meiosis specific and cooperates with protein phosphatase 2A to protect centromeric cohesin at meiosis I. The other shugoshin-like protein Sgo2, which requires theExpand
Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I
Aurora‐B kinases are important regulators of mitotic chromosome segregation, where they are required for the faithful bi‐orientation of sister chromatids. In contrast to mitosis, sister chromatidsExpand
Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis
Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeastExpand
Dissecting the first and the second meiotic divisions using a marker-less drug-hypersensitive fission yeast
Faithful chromosome segregation during meiosis is indispensable to prevent birth defects and infertility. Canonical genetic manipulations have not been very useful for studying meiosis II, sinceExpand
Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis
ABSTRACT Here, we screened a 10,371 library of diverse molecules using a drug-sensitive fission yeast strain to identify compounds which cause defects in chromosome segregation during mitosis. WeExpand
Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis
Summary All cellular proteins are synthesized by ribosomes, whose biogenesis in eukaryotes is a complex multi-step process completed within minutes. Several chemical inhibitors of ribosome functionExpand
Examining post‐translational modification‐mediated protein–protein interactions using a chemical proteomics approach
Post‐translational modifications (PTM) of proteins can control complex and dynamic cellular processes via regulating interactions between key proteins. To understand these regulatory mechanisms, itExpand