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MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
OBJECTIVE To elucidate the role of microRNA (miRNA) in the pathogenesis of rheumatoid arthritis (RA), we analyzed synoviocytes from RA patients for their miRNA expression. METHODS Synoviocytes… Expand
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.
The CCAAT/enhancer binding protein alpha (C/EBPalpha) protein is essential for proper lung and liver function and granulocytic and adipose tissue differentation. It was hypothesized that abnormalties… Expand
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome
- K. Arima, A. Kinoshita, +27 authors K. Yoshiura
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 August 2011
Nakajo-Nishimura syndrome (NNS) is a disorder that segregates in an autosomal recessive fashion. Symptoms include periodic fever, skin rash, partial lipomuscular atrophy, and joint contracture. Here,… Expand
A Novel Serum Metabolomics-Based Diagnostic Approach for Colorectal Cancer
Background To improve the quality of life of colorectal cancer patients, it is important to establish new screening methods for early diagnosis of colorectal cancer. Methodology/Principal Findings We… Expand
Diagnostic Accuracy of Serum 1,3-β-d-Glucan for Pneumocystis jiroveci Pneumonia, Invasive Candidiasis, and Invasive Aspergillosis: Systematic Review and Meta-Analysis
- Akira Onishi, D. Sugiyama, +6 authors S. Kumagai
- Medicine, Biology
- Journal of Clinical Microbiology
- 9 November 2011
ABSTRACT Serum 1,3-β-d-glucan (BG) assay may be helpful as a marker for the diagnosis of Pneumocystis jiroveci pneumonia (PJP) and invasive fungal infection (IFI). We conducted a systematic review to… Expand
Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis
Context Are autoantibodies against cyclic citrullinated peptide (CCP) better serum markers for rheumatoid arthritis than rheumatoid factor (RF)? Contribution This meta-analysis of 86 studies found… Expand
Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection.
- R. Takenaka, Y. Kawahara, +14 authors Kazuhide Yamamoto
- Gastrointestinal endoscopy
- 1 November 2008
BACKGROUND Although endoscopic submucosal dissection (ESD) is expected to reduce the local recurrence of gastric cancers, we still experience cases of recurrence after an ESD. OBJECTIVE To… Expand
CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.
OBJECTIVE The PD-1 receptor, whose deficiency in mice causes autoimmune diseases such as arthritis, is considered to be a negative regulator of activated T cells and to play a crucial role in… Expand
Anti-Programmed Cell Death 1 Antibody Reduces CD4+PD-1+ T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice
Programmed cell death 1 (PD-1) is an immunosuppressive receptor that transduces an inhibitory signal into activated T cells. Although a single nucleotide polymorphism in the gene for PD-1 is… Expand
MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats
- Y. Nakamachi, Kenichiro Ohnuma, Kenichi Uto, Yoriko Noguchi, J. Saegusa, S. Kawano
- Medicine, Biology
- Annals of the rheumatic diseases
- 16 January 2015
Objective MicroRNAs (miRNAs) are small endogenous, non-coding RNAs that act as post-transcriptional regulators. We analysed the in vivo effect of miRNA-124 (miR-124, the rat analogue of human… Expand