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Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.
TLDR
It is reasonable to conclude that Metofluthrin will not have any hepatocarcinogenic activity in humans, at least at expected levels of exposure, based on analysis with the International Life Sciences Institute/Risk Science Institute MOA framework. Expand
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.
TLDR
Results provide further evidence that the MOA for MTF-induced rat liver tumour formation is similar to that of PB and some other non-genotoxic CYP2B form inducers and that the key event of increased cell proliferation would not occur in human liver. Expand
Lipid Metabolic Reprogramming in Hepatocellular Carcinoma
TLDR
The latest findings regarding the role of FA metabolism pathways in hepatocarcinogenesis are discussed, focusing on obesity- and NASH-driven lipid metabolic reprogramming. Expand
Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes
TLDR
The data suggest that the MOA for metofluthrin-induced rat liver tumour formation is not relevant for humans and hence that metof luthrin does not pose a carcinogenic hazard for humans. Expand
Cloning and comparative characterization of three distinct nucleopolyhedroviruses isolated from the common cutworm, Spodoptera litura (Lepidoptera : Noctuidae) in Japan
TLDR
The results indicate that the natural heterogeneity of baculoviruses can be exploited to develop NPV strains suitable for the control of S. litura and suggest that the novel SpltNPV-C3 isolated in this study has high potential to be developed as an effective pest control agent for S.litura. Expand
Biological characteristics: growth and development of the egg parasitoid Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) on the cabbage armyworm Mamestra brassicae (Lepidoptera: Noctuidae)
TLDR
The growth and development of Trichogramma dendrolimi in the host, Mamestra brassicae, egg was morphologically observed and the parasitoid wasp appears to arrest the development of the host by a venom. Expand
Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized
TLDR
Although NaPB could activate CAR in both rodent and human hepatocytes, NaPB did not increase replicative DNA synthesis in human hepatocyte-originated areas of chimeric mice, whereas it was mitogenic to rat and mouse hepatocytes. Expand
Enhanced rat Hershberger assay appears reliable for detection of not only (anti-)androgenic chemicals but also thyroid hormone modulators.
TLDR
The findings in the present study suggest that the enhanced Hershberger assay, with evaluation of thyroid histopathology and weights, and hormone levels, appears to be reliable for screening for not only (anti-)androgenic chemicals but also thyroid hormone modulators. Expand
Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.
TLDR
The results suggest that the decreased serum levels of palmitolesic acid in rats with PDAC was likely due to its decrease in pancreatic tissue and that palmitoleic acid should be investigated in human samples to assess its diagnostic significance as a serum biomarker for human PDAC. Expand
Functional genomics may allow accurate categorization of the benzimidazole fungicide benomyl: lack of ability to act via steroid-receptor-mediated mechanisms.
TLDR
The findings suggest the decreased organ weights observed in vivo to be caused by mechanisms that are not steroid-receptor-mediated, such as interfering with assembly of microtubules by benomyl. Expand
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