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Time-Dependent Reorganization of the Brain Components Underlying Memory Retention in Trace Eyeblink Conditioning
Many studies have confirmed the time-limited involvement of the hippocampus in mnemonic processes and suggested that there is reorganization of the responsible brain circuitry during memoryExpand
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Classical eyeblink conditioning in glutamate receptor subunit δ2 mutant mice is impaired in the delay paradigm but not in the trace paradigm
In mice lacking glutamate receptor subunit δ2 (GluRδ2–/– mice), cerebellar long‐term depression (LTD) at the parallel fibre–Purkinje cell synapses is disrupted. Unlike the cerebellar LTD‐deficientExpand
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Time-limited role of the hippocampus in the memory for trace eyeblink conditioning in mice
We examined the role of the hippocampus in memory retention after trace eyeblink conditioning in mice. After establishing the conditioned response (CR) in the trace paradigm, mice received aExpand
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NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace, but not delay eyeblink conditioning.
Permanent lesions in the medial prefrontal cortex (mPFC) affect acquisition of conditioned responses (CRs) during trace eyeblink conditioning and retention of remotely acquired CRs. To clarifyExpand
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Systems Consolidation Requires Postlearning Activation of NMDA Receptors in the Medial Prefrontal Cortex in Trace Eyeblink Conditioning
The importance of the hippocampus in declarative memory is limited to recently acquired memory, and remotely acquired memory is believed to be stored somewhere in the neocortex. However, it remainsExpand
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Differential Regulation of Synaptic Plasticity and Cerebellar Motor Learning by the C-Terminal PDZ-Binding Motif of GluRδ2
The δ2 glutamate receptor (GluRδ2) is predominantly expressed in Purkinje cells and plays crucial roles in cerebellar functions: GluRδ2−/− mice display ataxia and impaired motor learning. InExpand
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Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit epsilon 1.
To elucidate the role of the N-methyl-D-aspartate (NMDA) -type glutamate receptor subunit epsilon 1 (GluR epsilon 1) in classical eyeblink conditioning, delay and trace eyeblink conditioning wereExpand
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Impaired delay but normal trace eyeblink conditioning in PLCβ4 mutant mice
To elucidate the functional role of phospholipase Cβ4 (PLCβ4), which is highly expressed in the Purkinje cells of the rostral cerebellum, cerebellar long-term depression (LTD) and delay and traceExpand
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mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning
In metabotropic glutamate receptor‐subtype 1 (mGluR1)‐null (mGluR1–/–) mice, cerebellar long‐term depression (LTD) and several forms of memory are impaired. However, because mGluR1 is expressed inExpand
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