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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
B lymphocytes have critical roles as positive and negative regulators of immunity. Their inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell-derived IL-10 canExpand
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How can immunology contribute to the control of tuberculosis?
  • S. Kaufmann
  • Biology, Medicine
  • Nature Reviews Immunology
  • 1 October 2001
Tuberculosis poses a significant threat to mankind. Multidrug-resistant strains are on the rise, and Mycobacterium tuberculosis infection is often associated with human immunodeficiency virusExpand
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Mycobacterium tuberculosis: success through dormancy.
Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around this globe, annually. The only vaccine, developed almost a century ago, provides limited protection onlyExpand
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Iron and microbial infection
Nature Rev. Microbiol. 2, 946–953 (2004) The citation given to support the statement that the solubility of Fe(OH)2+ at pH 7 is 1.4 × 10−9 was incorrect, and should be: 3. Chipperfield, J. R. &Expand
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Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location.
Due to the dependency on aromatic precursors, the growth of Salmonella typhimurium aroA- is limited in immunocompetent mice. Here we show that H-21-A beta-/- mice (lacking MHC class II molecules andExpand
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Malnutrition and Infection: Complex Mechanisms and Global Impacts
The authors discuss current concepts and controversies surrounding the complex influences of malnutrition on infection and immunity, and point to practical consequences of countermeasures in acuteExpand
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Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon.
Susceptibility of mice to infection with Yersinia enterocolitica has been shown to be related to neither the Ity locus encoding for resistance to Salmonella typhimurium and other pathogens nor theExpand
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Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.
CD8 T lymphocytes are important effectors in protective immunity against Mycobacterium tuberculosis. We recently characterized the detour pathway of CD8 T cell activation in tuberculosis mediated byExpand
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Notch signaling is activated by TLR stimulation and regulates macrophage functions
Notch signaling is a well‐conserved pathway involved in cell fate decisions, proliferation and apoptosis. We report on the involvement of Notch signaling in regulating gene expression in activatedExpand
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Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin.
The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was shown to improveExpand
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