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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
The increased immunity found in mice lacking IL-35 production by B cells was associated with a higher activation of macrophages and inflammatory T cells, as well as an increased function of B cells as antigen-presenting cells (APCs).
How can immunology contribute to the control of tuberculosis?
- S. Kaufmann
- Medicine, BiologyNature Reviews Immunology
- 1 October 2001
A clear understanding of the immune responses that control the pathogen will be important for achieving optimal immunity, and information provided by functional genome analysis of M. tuberculosis will be vital in the design of a future vaccine.
Mycobacterium tuberculosis: success through dormancy.
The molecular mechanisms underlying Mycobacterium tuberculosis's ability to shut down its own central metabolism, terminate replication, and thereby transit into a stage of dormancy rendering itself extremely resistant to host defense and drug treatment are reviewed.
Iron and microbial infection
The citation given to support the statement that the solubility of Fe(OH)2+ at pH 7 is 1.4 × 10−9 was incorrect, and should be: 3.4×10−9.
Malnutrition and Infection: Complex Mechanisms and Global Impacts
The authors discuss current concepts and controversies surrounding the complex influences of malnutrition on infection and immunity, and point to practical consequences of countermeasures in acute…
Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location.
The sublethal inocula of S. typhimurium aroA- led to permanent infection in H-21-A beta-/- mice, suggesting that bacterial starvation is insufficient for sterile clearance in immunocompetent mice and that MHC class II-dependent immune mechanisms are required for pathogen eradication.
Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.
Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin.
- L. Grode, P. Seiler, S. Kaufmann
- Biology, MedicineThe Journal of clinical investigation
- 1 September 2005
The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was shown to improve…
New insights into the function of granulomas in human tuberculosis
Investigations on human lung granulomas aimed at better understanding the regional host response and counter‐measures to Mycobacterium tuberculosis lead to a revised view of the regional immune response in human tuberculosis.
Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
A new 'detour' pathway for presentation of antigens from a phagosome-contained pathogen shows the functional significance of infection-induced apoptosis in the activation of CD8 T cells specific for both protein and glycolipid antigENS in tuberculosis.