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Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review.
- T. Maack, V. A. Johnson, S. Kau, J. Figueiredo, D. Sigulem
- Biology, Medicine
- Kidney international
- 1 September 1979
Low-molecular-weight proteins are a heterogenous group of substances which constitute a small but biologically important fraction of total circulating proteins. The group comprises enzymes (for… Expand
A method for screening diuretic agents in the rat.
A reproducible screening method for diuretic agents has been developed based upon the selection of a group of homogenous rats with a similar excretory pattern of water and electrolytes. Normal saline… Expand
Transport and catabolism of parathyroid hormone in isolated rat kidney.
Zeneca ZD6169 and its analogs from a novel series of anilide tertiary carbinols: in vitro KATP channel opening activity in bladder detrusor.
The potassium (K+) channel opening activity of Zeneca ZD6169 and one of its pyridylsulfonyl analogs from the anilide tertiary carbinol series was ascertained. Their mechanoinhibitory effects on the… Expand
A sciatic nerve blockade method to differentiate drug-induced local anesthesia from neuromuscular blockade in mice.
This report introduces a simple and easy technique for animal handling and drug administration into the sciatic nerve area for determining local anesthesia and neuromuscular blocking activity in… Expand
Comparative effects of intravesical versus extravesical administration of ZD6169 and cromakalim on the response of the in vitro rat whole bladder to field stimulation.
Potassium channel openers are currently being evaluated for their inhibitory effect on hyperreflexia. Increasing potassium permeability results in a hyperpolarization of the smooth muscle membrane… Expand
Chromatographic separation of the venom of Bungarus multicinctus and characterization of its components.
The venom of Bungarus multicincius has been fractionated on a CM-Sephadex C-50 column into eight major fractions by gradient elution with 0.05–1.0 M ammonium acetate buffer at pH Fraction I is… Expand
Studies of the K(ATP) channel opening activity of the new dihydropyridine compound 9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione in bladder detrusor in vitro.
The potassium (K+) channel opening activity of ZM244085 (9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione, CAS 149398-59-4), a novel dihydropyridine (DHP), was ascertained. In a… Expand
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
The effects of K+ channel openers and blockers on smooth muscles of vascular and nonvascular origin from guinea pigs have been investigated. Cromakalim, pinacidil, nicorandil and minoxidil sulfate… Expand
β-adrenoceptor subtypes in the detrusor of guinea-pig urinary bladder
β-Adrenoceptors have been demonstrated in the urinary bladders of many animals including the guinea pig. However, there is little information on the subtypes involved in the antispasmodic activity of… Expand