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An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physicalExpand
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An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physicalExpand
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Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
High‐throughput techniques have identified numerous antisense (AS) transcripts and long non‐coding RNAs (ncRNAs). However, their significance in cancer biology remains largely unknown. Here, weExpand
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The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves.
BACKGROUND Pruritus is a cardinal symptom of atopic dermatitis, and an increased cutaneous sensory network is thought to contribute to pruritus. Although the immune cell-IL-31-neuron axis has beenExpand
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Microbe-host interplay in atopic dermatitis and psoriasis
Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparativeExpand
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Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes
Background The nuclear factor &kgr; light‐chain enhancer of activated B cells (NF‐&kgr;B) signaling pathway is a key regulator of immune responses. Accordingly, mutations in several NF‐&kgr;B pathwayExpand
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Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development
Transcriptional program that drives human preimplantation development is largely unknown. Here, by using single-cell RNA sequencing of 348 oocytes, zygotes and single blastomeres from 2- to 3-day-oldExpand
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Single-cell transcriptome analysis of endometrial tissue
STUDY QUESTION How can we study the full transcriptome of endometrial stromal and epithelial cells at the single-cell level? SUMMARY ANSWER By compiling and developing novel analytical tools forExpand
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Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate
Significance Prostate cancer is an androgen receptor (AR)-dependent disease. Goals in treatment of prostate cancer include keeping low Gleason grades low and preventing development of the lethalExpand
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Identification of region‐specific transcription factor genes in the adult mouse brain by medium‐scale real‐time RT‐PCR
We established a medium‐scale real‐time RT‐PCR system focusing on transcription factors and applied it to their expression profiles in the adult mouse 11 brain regionsExpand
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