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Systemic hemodynamics and regional blood flow during chronic nitric oxide synthesis inhibition in pregnant rats.
Pregnancy-induced hypertension in women is associated with severe vasoconstriction and reductions in organ blood flow and cardiac output. Recent studies have indicated that nitric oxide (NO)Expand
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Intrauterine endotoxin infusion in rat pregnancy induces preterm delivery and increases placental prostaglandin F2alpha metabolite levels.
OBJECTIVE This study was designed to examine the effects of intrauterine endotoxin (lipopolysaccharide) on rat pregnancy. STUDY DESIGN Pregnant Sprague-Dawley rats (N = 26) were implanted withExpand
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Mechanisms of Obesity-Induced Hypertension
ABSTRACT Obesity is a major cause of human essential hypertension. Recent studies point toward increased renal tubular reabsorption and abnormal renal pressure natriuresis in mediating obesity hype...
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Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats.
The aim of this study was to examine the role of endothelin-A (ET(A)) receptors in mediating the hypertension and renal injury associated with high salt intake in Dahl salt-sensitive (DS) rats. ToExpand
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Endothelin antagonists improve renal function in spontaneously hypertensive rats.
Hypertension in the spontaneously hypertensive rat (SHR) is associated with reduced renal excretory function, low renal plasma flow, reduced glomerular filtration rate, and reduced renal interstitialExpand
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Role of nitric oxide in modulating renal function and arterial pressure during chronic aldosterone excess.
Chronic aldosterone (Aldo) excess is associated with transient sodium retention, extracellular fluid volume expansion, renal vasodilation, and hypertension. The purpose of this study was to determineExpand
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Reduced sensitivity of the renal circulation to angiotensin II in pregnant rats.
The renal circulation undergoes significant changes during pregnancy and pregnancy-induced hypertension. Although numerous studies indicate that the pressor response to angiotensin II (Ang II) isExpand
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Association of methylenetetrahydrofolate reductase (C677T) polymorphism with hyperuricemia.
BACKGROUND AND AIMS Homozygosity for the thermolabile variant of 5,10-methylene tetrahydrofolate reductase (C677T) has been suggested to be positively associated with the risk of vascular disease andExpand
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Chronic endothelin-induced pressor and renal actions in conscious dogs do not require altered ANG II formation.
Plasma endothelin levels are elevated approximately two- to threefold in a number of chronic pathophysiological conditions associated with hypertension. Results from recent studies indicate anExpand
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Blunted natriuretic response to a high-sodium meal in obese dogs. Role of renal nerves.
Although the relation between body weight and arterial pressure is well established, the mechanisms involved in the pathogenesis of obesity-related hypertension are unclear. However, recent studiesExpand
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  • Open Access