Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
- S. Maynard, J. Min, +10 authors S. Karumanchi
- Medicine
- 1 March 2003
Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia remains largely unknown. It has been… Expand
Soluble endoglin contributes to the pathogenesis of preeclampsia
- S. Venkatesha, M. Toporsian, +16 authors S. Karumanchi
- Medicine
- Nature Medicine
- 30 May 2006
Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial maternal and fetal morbidity and mortality. Maternal endothelial dysfunction mediated by excess placenta-derived… Expand
Vitamin D-binding protein and vitamin D status of black Americans and white Americans.
- Camille E. Powe, M. Evans, +9 authors R. Thadhani
- Medicine
- The New England journal of medicine
- 20 November 2013
BACKGROUND
Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency.
METHODS
In the… Expand
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
- S. Maynard, Jiang-Yong Min, +10 authors S. Karumanchi
- Medicine
- The Journal of clinical investigation
- 1 September 2003
Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia remains largely unknown. It has been… Expand
Circulating angiogenic factors and the risk of preeclampsia*
- R. Levine, S. Maynard, +10 authors S. Karumanchi
- Medicine
- The New England journal of medicine
- 12 February 2004
BACKGROUND
The cause of preeclampsia remains unclear. Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular… Expand
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
- R. Levine, Chun Lam, +8 authors S. Karumanchi
- Medicine
- The New England journal of medicine
- 7 September 2006
BACKGROUND
Alterations in circulating soluble fms-like tyrosine kinase 1 (sFlt1), an antiangiogenic protein, and placental growth factor (PlGF), a proangiogenic protein, appear to be involved in the… Expand
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
- C. Wei, Shafic El Hindi, +25 authors J. Reiser
- Biology, Medicine
- Nature Medicine
- 1 August 2011
Focal segmental glomerulosclerosis (FSGS) is a cause of proteinuric kidney disease, compromising both native and transplanted kidneys. Treatment is limited because of a complex pathogenesis,… Expand
Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans
- Samir M. Parikh, T. Mammoto, +4 authors V. Sukhatme
- Medicine
- PLoS medicine
- 24 January 2006
Background Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in… Expand
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients…
- R. Romero, J. Nien, +12 authors S. Karumanchi
- Medicine
- The journal of maternal-fetal & neonatal medicine…
- 1 January 2008
Introduction. Accumulating evidence suggests that an imbalance between pro-angiogenic (i.e., vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)) and anti-angiogenic factors… Expand
Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium
- H. T. Yuan, E. Khankin, S. Karumanchi, Samir M. Parikh
- Biology, Medicine
- Molecular and Cellular Biology
- 17 February 2009
ABSTRACT Angiopoietin 2 (Ang2) was originally shown to be a competitive antagonist for Ang1 of the receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted on… Expand