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  • Influence
Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell
In a recent study of the corpus epithelium in the mouse stomach, eleven cell types have been identified and enumerated (Karam and Leblond: Anat. Rec. 232:231–246, 1992). The dynamics of these cellsExpand
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Lineage commitment and maturation of epithelial cells in the gut.
  • S. Karam
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual…
  • 15 March 1999
The dynamic concepts of gut epithelial cell populations which heralded the era of modern gut cell biology have been generally substantiated by recent studies and are still being correlated withExpand
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Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide.
BACKGROUND & AIMS This study looked for new proteins with expression restricted to the gastric epithelium that may provide insight to the differentiation and function of the gastric unit. METHODS AExpand
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Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells
The pit cells (or surface mucous cells) present along pit walls and gastric surface have been investigated by electron microscopy and radioautography after a pulse or continuous infusion ofExpand
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Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cells
The neck cells (or mucous neck cells) present in the neck region and the zymogenic cells (or chief cells) present in the base region of the units in the mouse corpus were examined in the electronExpand
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A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype.
Human neuroendocrine cancers (NECs) arise in various endoderm-derived epithelia, have diverse morphologic features, exhibit a wide range of growth phenotypes, and generally have obscure cellularExpand
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Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss
  • S. Karam
  • Biology, Medicine
  • The Anatomical record
  • 1 June 1993
The life story of parietal cells has been investigated in the corpus of the mouse stomach using electron microscopy and 3H‐thymidine radioautography. Parietal cells are scattered in the four regionsExpand
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Defining Epithelial Cell Progenitors in the Human Oxyntic Mucosa
In the human stomach, the oxyntic epithelium includes numerous tubular invaginations consisting of short pits opening into long glands. The pit is lined by pit cells, whereas the gland is composed ofExpand
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Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference
Recent work suggests that stomach-derived hormone ghrelin receptor (GHS-R1A) antagonism may reduce motivational aspects of ethanol intake. In the current study we hypothesized that the endogenousExpand
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Potential role of probiotics in the management of gastric ulcer
Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequentExpand
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