Idiopathic hypothalamic diabetes insipidus, pituitary stalk thickening, and the occult intracranial germinoma in children and adolescents.
- S. Mootha, A. Barkovich, F. Conte
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 May 1997
So-called "idiopathic" central diabetes insipidus warrants close follow-up to determine the etiology, especially if anterior pituitary hormone deficiencies are detected.
Effect of growth hormone (GH)-releasing hormone (GRH) on plasma GH in relation to magnitude and duration of GH deficiency in 26 children and adults with isolated GH deficiency or multiple pituitary…
- E. Schriock, R. Lustig, S. Rosenthal, S. Kaplan, M. Grumbach
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 June 1984
The GH responses to GRH suggest that the majority of patients with isolated GHD as well as those with multiple hypothalamic-pituitary hormone deficiencies have deficiency of hypothalamic GRH .
Endocrine and neurologic outcome in childhood craniopharyngioma: Review of effect of treatment in 42 patients.
- M. Thomsett, F. Conte, S. Kaplan, M. Grumbach
- MedicineJornal de Pediatria
- 1 November 1980
Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing's disease.
- D. J. Devoe, W. Miller, S. Gitelman
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 October 1997
It is concluded that transsphenoidal surgery is a safe and effective treatment for pediatric Cushing's disease, but long-term surveillance is necessary to detect possible recurrences.
Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5 years.
- D. Paul, F. Conte, M. Grumbach, S. Kaplan
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 February 1995
The salutary effects of long term GnRH agonist therapy on stature are more clear-cut in the younger treated children, and young untreated children may have the worst outcome with respect to final height.
A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis.
- F. Conte, M. Grumbach, S. Kaplan
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 April 1975
The similarity of pattern of Gonadotropin secretion observed between patients with gonadal dysgenesis and normal children suggests that gonadal function does not play a decisive role in the pattern of gonadotropic secretion from infancy through adolescence, but exercises striking effects on the quantity of gonADotropin secreted.
The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency: evidence for a direct role of sex steroids.
- K. Attie, N. R. Ramírez, F. Conte, S. Kaplan, M. Grumbach
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 October 1990
It is concluded that a substantial pubertal growth spurt can occur in patients with true precocious puberty and GH deficiency that is dependent on gonadal sex steroids yet unaccompanied by normal Pubertal levels of circulating GH or IGF-I.
Somatomedin-C levels in children and adolescents with gonadal dysgenesis: differences from age-matched normal females and effect of chronic estrogen replacement therapy.
- L. Cuttler, G. Van Vliet, F. Conte, S. Kaplan, M. Grumbach
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 June 1985
It is suggested that increasing endogenous estrogen production is a major determinant of the rise of circulating Sm-C that occurs during pubertal development in normal girls.
Clinical review 14: Pathophysiology and treatment of sexual precocity.
- S. Kaplan, M. Grumbach
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 October 1990
The complex maturational changes in both organization and activation of the hypothalamic GnRH-pituitary gonadotropin-gonadal system can be viewed as a continuum extending from its ontogeny in the…
Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
- J. Lo, V. Schwitzgebel, M. Grumbach
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 March 1999
Pregnancy outcomes and serial measurements of maternal serum steroid levels in four women with classic 21-hydroxylase deficiency, three of whom were female pseudohermaphrodites with the salt-losing form, highlight key issues in the management of pregnancy in women with 21-Hydroxylases deficiency, particularly the use of endocrine monitoring to assess adrenal androgen suppression in the mother, especially when the fetus is female.
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