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Idiopathic hypothalamic diabetes insipidus, pituitary stalk thickening, and the occult intracranial germinoma in children and adolescents.
So-called "idiopathic" central diabetes insipidus warrants close follow-up to determine the etiology, especially if anterior pituitary hormone deficiencies are detected. Expand
Effect of growth hormone (GH)-releasing hormone (GRH) on plasma GH in relation to magnitude and duration of GH deficiency in 26 children and adults with isolated GH deficiency or multiple pituitary
The GH responses to GRH suggest that the majority of patients with isolated GHD as well as those with multiple hypothalamic-pituitary hormone deficiencies have deficiency of hypothalamic GRH . Expand
Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5 years.
The salutary effects of long term GnRH agonist therapy on stature are more clear-cut in the younger treated children, and young untreated children may have the worst outcome with respect to final height. Expand
Gonadotropin-independent familial sexual precocity with premature Leydig and germinal cell maturation (familial testotoxicosis): effects of a potent luteinizing hormone-releasing factor agonist and
Four boys with sexual precocity are described in whom pubertal concentrations of plasma testosterone were associated with premature Leydig and germinal cell maturation without activation of the hypothalamic-pituitary gonadotropin unit, and the term "familial testotoxicosis" is proposed to describe this group of sexually precocious boys. Expand
Clinical review 14: Pathophysiology and treatment of sexual precocity.
The complex maturational changes in both organization and activation of the hypothalamic GnRH-pituitary gonadotropin-gonadal system can be viewed as a continuum extending from its ontogeny in theExpand
The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency: evidence for a direct role of sex steroids.
It is concluded that a substantial pubertal growth spurt can occur in patients with true precocious puberty and GH deficiency that is dependent on gonadal sex steroids yet unaccompanied by normal Pubertal levels of circulating GH or IGF-I. Expand
Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing's disease.
It is concluded that transsphenoidal surgery is a safe and effective treatment for pediatric Cushing's disease, but long-term surveillance is necessary to detect possible recurrences. Expand
Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Pregnancy outcomes and serial measurements of maternal serum steroid levels in four women with classic 21-hydroxylase deficiency, three of whom were female pseudohermaphrodites with the salt-losing form, highlight key issues in the management of pregnancy in women with 21-Hydroxylases deficiency, particularly the use of endocrine monitoring to assess adrenal androgen suppression in the mother, especially when the fetus is female. Expand
Growth and Growth Hormone
Abstract Human growth hormone (HGH) deficiency was documented by radioimmunoassay in 35 patients — 16 with isolated HGH, 7 HGH and TSH, 4 HGH and ACTH, and 8 HGH, TSH and ACTH deficiencies. Of 15 p...
Evidence for Parathyroid Failure in Magnesium Deficiency
Findings support the view that magnesium depletion may result in impaired synthesis or release of parathyroid hormone in man, or both. Expand