• Publications
  • Influence
[Effects of propiverine hydrochloride (P-4) and its metabolites on urinary bladder function in anesthetized rats].
TLDR
The results suggest that the clinical effects of P-4 are based not only on the actions ofP-4 itself but also on those of its active metabolites.
[Effects of propiverine hydrochloride (propiverine) on isolated rat and dog urinary bladder].
TLDR
Although propiverine exhibits both anti-muscarinic and anti-KCl effects in isolated rat and dog urinary bladder, the inhibitory effects of propiverines on the atropine-resistant part of contraction may be mainly due to its anti- KCl effect.
[Effect of propiverine hydrochloride on the function of the bladder in dogs].
TLDR
Findings indicate that P-4 is a useful drug for the treatment of pollakiuria, which is a new derivative of benzilic acid that causes a significant increase in maximum vesical volume.
[Effect of propiverine hydrochloride on the function of the bladder in decerebrated dogs].
TLDR
It is shown that P-4 is a useful drug for the treatment of pollakiuria and at the dose level of 2, 5 and 10 mg/kg, i.v, it significantly increased effective vesical volume when determined by cystometry.
[Effects of propiverine hydrochloride (propiverine) on the muscarinic receptor binding affinity in guinea pig tissues and on salivation in conscious dogs].
TLDR
Although propiverine, its active metabolite DPr-P-4 (N-->O), oxybutynin and terodiline competitively inhibit the binding of 3H-QNB to muscarinic receptors, the affinity of these drugs for the mus carinic receptors of these tissues is very different and that propiverines has less effect on salivation than oxybutlynin.
[Mode of inhibitory action of propiverine hydrochloride on the micturition movements of the bladder in dogs].
TLDR
The findings suggest that the inhibition of the vesico-detrusor reflex by P-4 may result from its inhibitory action on the efferent terminal of the pelvic nerve.
[New therapeutic strategies for cerebrovascular diseases based on the control of intra-cerebral inflammation].
  • H. Katsuki, S. Kaneko
  • Chemistry, Medicine
    Nihon yakurigaku zasshi. Folia pharmacologica…
  • 1 September 2014
[Automated electrophysiological system for the measurement of transporter/channel activities].
  • S. Kaneko
  • Chemistry, Medicine
    Nihon yakurigaku zasshi. Folia pharmacologica…
  • 1 December 2011
[The fourth revision of the Medical Treatment Law and future problems].
  • S. Kaneko
  • Medicine
    Seishin shinkeigaku zasshi = Psychiatria et…
  • 2001
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