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Idiopathic Pulmonary Alveolar Proteinosis as an Autoimmune Disease with Neutralizing Antibody against Granulocyte/Macrophage Colony-Stimulating Factor
- T. Kitamura, N. Tanaka, K. Nakata
- Medicine, BiologyThe Journal of experimental medicine
- 20 September 1999
It is strongly suggested that neutralization of GM-CSF bioactivity by the antibody causes dysfunction of alveolar macrophages, which results in reduced surfactant clearance.
Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis
It is shown that a unique clathrin heavy-chain repeat homology protein, FROUNT, directly bound activated CCR2 and formed clusters at the cell front during chemotaxis and could be a therapeutic target in chronic inflammatory immune diseases associated with macrophage infiltration.
Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue*
Evidence is provided that bone marrow cells from wild type mice migrate directly toward MCP-1 or culture medium conditioned by adipose tissue explants of genetically obese ob/ob mice, which are efficiently suppressed by pharmacological blockade of CCR2 signaling.
A novel optical assay system for the quantitative measurement of chemotaxis.
Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency
- F. Ishibashi, H. Nunoi, F. Endo, I. Matsuda, S. Kanegasaki
- Biology, MedicineHuman Genetics
- 10 May 2000
Based on the present and reported data from Japan, the molecular defects of the disease and the difference in statistics between western countries and Japan are discussed.
Human Ecalectin, a Variant of Human Galectin-9, Is a Novel Eosinophil Chemoattractant Produced by T Lymphocytes*
The finding that the ecalectin transcript is present in abundance in various lymphatic tissues and that its expression increases substantially in antigen-activated peripheral blood mononuclear cells suggests that ecalECTin is an important T-cell-derived regulator of eosinophil recruitment in tissues during inflammatory reactions.
Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication in the lung.
- K. Nakata, W. Rom, M. Weiden
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 1 March 1997
The conclusion that pulmonary tuberculosis enhances local HIV-1 replication in vivo is supported, using bronchoalveolar lavage of patients with pulmonary tuberculosis to investigate the in vivo effect of coinfection of Mycobacterium tuberculosis on human immunodeficiency virus type 1 replication.
Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte‐macrophage colony stimulating factor
Enhancement of Antitumor Radiation Efficacy and Consistent Induction of the Abscopal Effect in Mice by ECI301, an Active Variant of Macrophage Inflammatory Protein-1α
Marked inhibition of tumor growth at the irradiated site, with complete tumor eradication and consistent induction of the abscopal effect, was potentiated by i.v. administration of ECI301, suggesting a new concept for cancer therapy, namely chemokine administration after local irradiation, leading to development of novel therapeutics for the treatment of advanced metastatic cancer.
Superoxide release and NADPH oxidase components in mature human phagocytes: correlation between functional capacity and amount of functional proteins.
- M. Yagisawa, A. Yuo, F. Takaku
- Biology, MedicineBiochemical and biophysical research…
- 12 November 1996
An overall positive interrelationship between protein content and its responsible function is indicated, though only gp91-phox was not associated with the functional capacity and low amounts of this component supported the increased respiratory burst activity of eosinophils.