• Publications
  • Influence
Clinical Utility of Measuring Infliximab and Human Anti-Chimeric Antibody Concentrations in Patients With Inflammatory Bowel Disease
TLDR
Measurement of HACA and infliximab concentration impacts management and is clinically useful, whereas in patients with subtherapeutic inflIXimab concentrations, this strategy may be a good alternative to changing to another anti-TNF agent. Expand
Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis.
TLDR
Nonadherence with medication increases the risk of clinical relapse among patients with quiescent ulcerative colitis and future research should be directed at behavioral interventions to improve adherence. Expand
Fecal Lactoferrin Is a Sensitive and Specific Marker in Identifying Intestinal Inflammation
TLDR
Fecal lactoferrin is sensitive and specific for detecting inflammation in chronic IBD and may prove useful in screening for inflammation in patients presenting with abdominal pain and diarrhea. Expand
Inflammatory Bowel Disease Characteristics Among African Americans, Hispanics, and Non-Hispanic Whites: Characterization of a Large North American Cohort
TLDR
There are racial differences in IBD family history, disease location and behavior, surgical history, and EIMs that may reflect underlying genetic variations and have important implications for diagnosis and management of disease. Expand
The Effect of a Nonabsorbed Oral Antibiotic (Rifaximin) on the Symptoms of the Irritable Bowel Syndrome
TLDR
Whether the nonabsorbed antibiotic rifaximin is more effective than placebo in reducing symptoms in adults with IBS is determined. Expand
An Evidence-Based Systematic Review on Medical Therapies for Inflammatory Bowel Disease
TLDR
Both UC and CD exhibit a relapsing and remitting course and there is a reduced quality of life during exacerbations of the disease, which has an impact on psychological health, with active IBD patients experiencing greater levels of distress and feelings of lack of sense of self-control compared with the normal population and patients with inactive IBD. Expand
Pregnancy outcomes in women with inflammatory bowel disease: a large community-based study from Northern California.
TLDR
Women with IBD are more likely to have an adverse outcome related to pregnancy and disease activity and medical treatment did not predict adverse outcomes in a large, nonreferral population. Expand
Efficacy of 5-Aminosalicylates in Ulcerative Colitis: Systematic Review and Meta-Analysis
TLDR
5-ASAs are highly effective for inducing remission and preventing relapse in UC, and evidence suggests that doses of ≥2.0 g/day have greater efficacy, although doses >2.5 G/day do not appear to lead to higher remission rates. Expand
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
TLDR
The data show that MLCK expression and enzymatic activity are increased in IBD, and the correlation with disease activity suggests that M LCK upregulation may contribute to barrier dysfunction and IBD pathogenesis. Expand
Systematic review: adherence issues in the treatment of ulcerative colitis
  • S. Kane
  • Medicine
  • Alimentary pharmacology & therapeutics
  • 1 March 2006
TLDR
First‐line therapy for ulcerative colitis is 5‐aminosalicylic acid, which suffers from poor patient adherence outside the clinical trial setting. Expand
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