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Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis
ABSTRACT We report the identification and molecular characterization of Pex19p, an oleic acid-inducible, farnesylated protein of 39.7 kDa that is essential for peroxisome biogenesis in Saccharomyces…
Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p 1
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism
- S. Kammerer, L. L. Burns-Hamuro, A. Braun
- Biology, MedicineProceedings of the National Academy of Sciences…
- 19 March 2003
This study suggests that alterations in PKA-RIα subcellular localization caused by variation in d-AKAP2 may have a negative health prognosis in the aging population, which may be related to cardiac dysfunction.
Role of ICAM1 in invasion of human breast cancer cells.
The results corroborate the previous genetic finding that variations in the ICAM region are associated with the occurrence of metastases and establish a causal role of ICAM1 in invasion of metastatic human breast carcinoma cell lines.
Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G.
- A. Muntau, P. Mayerhofer, B. Paton, S. Kammerer, A. Roscher
- Biology, MedicineAmerican journal of human genetics
- 1 October 2000
The observation of peroxisomal formation in the absence of morphologically recognizable peroxISomal membranes challenges the theory that perox isomes arise exclusively by growth and division from preexisting peroxIsomes and establishes PEX3 as a key factor in early human perox Isome synthesis.
Identification of polymorphic sites of the human bradykinin B2 receptor gene.
- A. Braun, S. Kammerer, E. Böhme, B. Müller, A. Roscher
- BiologyBiochemical and biophysical research…
- 6 June 1995
These new genetic markers provide valuable tools to elucidate a potential role of a hereditary dysfunction of the B2 bradykinin receptor gene in disorders such as hypertension or ischemic heart disease.
Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus
A large-scale association study to identify genes that influence nonfamilial breast cancer risk using a collection of German cases and matched controls and >25,000 single nucleotide polymorphisms located within 16,000 genes identified one of the candidate loci located on chromosome 19p13.
Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells
- Josephine M. Atienza, R. Roth, M. Denissenko
- Biology, MedicineMolecular Cancer Therapeutics
- 1 March 2005
It is concluded that RAD21 is a novel target for developing cancer therapeutics that can potentially enhance the antitumor activity of chemotherapeutic agents acting via induction of DNA damage.
Primary structure of human PMP69, a putative peroxisomal ABC-transporter.
We have cloned the cDNA of a novel human ABC-half-transporter highly similar to peroxisomal ABC-half-transporters such as the adrenoleukodystrophy protein (ALDP) and the peroxisomal protein 70…
Association testing by DNA pooling: An effective initial screen
- A. Bansal, D. van den Boom, Andi W. Braun
- BiologyProceedings of the National Academy of Sciences…
- 10 December 2002
A proof of concept of the use of pooled DNA as a means of efficiently screening SNPs and prioritizing them for further study is provided, reducing the final number of SNPs that undergo full, sample-by-sample genotyping as well as the quantity of DNA used overall.