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Intermediates in the Transformation of Phosphonates to Phosphate by Bacteria
TLDR
The elucidation of the chemical steps for the biodegradation of alkylphosphonates shows how these compounds can be metabolized and recycled to phosphate.
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay
TLDR
A small-molecule inhibitor of ABHD16A that depletes lyso-PSs from cells, including lymphoblasts derived from subjects with PHARC, and these enzymes are designated as potential targets for treating neuroimmunological disorders.
A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines
TLDR
Activity-based protein profiling is used to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells.
Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.
TLDR
The data suggest that CEL might break down dietary FAHFAs, a pancreatic enzyme hydrolyzing cholesteryl esters and other dietary lipids, as a FAHFA hydrolase.
Amino-acid Synthesis from Hydrogen Cyanide under Possible Primitive Earth Conditions
TLDR
The direct formation of amino-acids from hydrogen cyanide is investigated for the first time in this laboratory.
AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs
TLDR
The results indicate that AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism and demonstrate how chemical proteomics can excavate potential cases of convergent/parallel protein evolution that defy conventional sequence- and structure-based predictions.
Catalytic mechanism and three-dimensional structure of adenine deaminase.
TLDR
This work provides the first example of any member of the deaminase subfamily of the amidohydrolase superfamily to utilize a binuclear metal center for the catalysis of a deamination reaction and proposes the roles for each of the highly conserved residues.
The enzymatic conversion of phosphonates to phosphate by bacteria.
Kinesin-dependent mechanism for controlling triglyceride secretion from the liver
TLDR
It is shown that kinesin motors are recruited to triglyceride-rich lipid droplets in the liver by the GTPase ARF1, which is a key activator of lipolysis and therefore responds to fed/fasted states of the animal.
Enzymatic deamination of the epigenetic base N-6-methyladenine.
TLDR
This is the first identification of an N-6-methyladenine deaminase (6-MAD) and a comparative model of Bh0637 was computed using the three-dimensional structure of Atu4426 (PDB code: 3NQB) as a structural template and computational docking was used to rationalize the preferential utilization of N- 6- methyladenine over adenine.
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