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BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
It is demonstrated that BMP2 is a necessary component of the signaling cascade that governs fracture repair and an endogenous mediator necessary for fracture repair in mice lacking the ability to produce B MP2 in their limb bones.
Enhanced Chondrogenesis and Wnt Signaling in PTH‐Treated Fractures
It is shown that PTH primarily enhanced the earliest stages of endochondral bone repair by increasing chondrocyte recruitment and rate of differentiation, and observed an increased level of canonical Wnt‐signaling in PTH‐treated bones at multiple time‐points across the time‐course of fracture repair, supporting the conclusion that P TH responses are at least in part mediated through Wnt signaling.
Diminished Bone Formation During Diabetic Fracture Healing is Related to the Premature Resorption of Cartilage Associated With Increased Osteoclast Activity
Histological and molecular analysis of fracture healing in normal and diabetic animals showed significantly enhanced removal of cartilage in diabetic animals. Increased cartilage turnover was
Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing.
Results suggest that TNF-alpha signaling in chondrocytes controls vascularization of cartilage through the regulation of angiopoietin and VEGI factors which play counterbalancing roles in the induction of growth arrest, or apoptosis in endothelial cells.
Prospective Comparison of Auto and Allograft Hamstring Tendon Constructs for ACL Reconstruction
The data suggest laxity is not increased in allograft tendons compared with autografts and clinical outcome scores 3 to 6 years after surgery are similar, and patients with a minimum followup of 3 years are likely to have similar results.
Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment.
This review focuses on the recent research demonstrating the potential of parathyroid hormone in the management of bone repair in a number of fracture models and also highlights the ongoing studies into the mechanisms of PTH actions on endochondral bone repair.